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Basal Cell Adenocarcinoma of the Sublingual Gland: A Case of an Inadequate FNA Cytology Specimen Rendering Conclusive Diagnosis Difficult | OMICS International | Abstract
ISSN: 2157-7099

Journal of Cytology & Histology
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Case Report

Basal Cell Adenocarcinoma of the Sublingual Gland: A Case of an Inadequate FNA Cytology Specimen Rendering Conclusive Diagnosis Difficult

Sohsuke Yamada1*, Noriko Tsunenari2, Atsunori Nabeshima1, Kosho Obara2, Hirotsugu Noguchi1, Aya Nawata1, Hidetaka Uramoto3 and Toshiyuki Nakayama1

 

1Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan

2Department of Diagnostic Pathology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan

3Department of Second Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan

*Corresponding Author:
Sohsuke Yamada, M.D., Ph.D.
Department of Pathology and Cell Biology
School of Medicine, University of Occupational and Environmental Health
1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan
Tel: 81-93-691-7426
Fax: 81-93-603-8518
E-mail: [email protected]

Received Date: September 11, 2014; Accepted Date: September 26, 2014; Published Date: September 28, 2014

Citation: Yamada S, Tsunenari N, Nabeshima A, Obara K, Noguchi H, et al. (2014) Basal Cell Adenocarcinoma of the Sublingual Gland: A Case of an Inadequate FNA Cytology Specimen Rendering Conclusive Diagnosis Difficult. J Cytol Histol 5:281. doi: 10.4172/2157-7099.1000281

Copyright: © 2014 Yamada S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

A history of a gradual increase in swelling mass was presented in the sublingual gland of a 72-year-old female. The inadequate cytologic specimens retrospectively contained some clusters of three-dimensional monomorphic and round basaloid cells having hyperchromatic small nuclei and scant cytoplasm, along with a small amount of spherical globules of amorphous material and myxoid stroma, adjacent to few squamous metaplastic tumor nests. We first interpreted it as a pleomorphic adenoma, basal cell adenoma (BCA), or adenoid cystic carcinoma (ACC). A tumor extirpation was performed, and gross examination revealed a non-capsulated and ill-defined tumor lesion, looking grayish to yellowish-white, focally associated with fat invasion. On microscopic examination, the tumor was predominantly composed of a proliferation of small to medium-sized mildly atypical epithelial cells having very rare mitoses, often arranged in a cribriform or alveolar growth pattern with peripheral nuclear palisading and scattered squamous differentiation, embedded in a prominent eosinophilic hyaline material. Therefore, we finally made a diagnosis of invasive basal cell adenocarcinoma (BCAC), defined as the malignant counterpart of benign BCA. We should be aware that owing to its characteristic features, cytopathologists might be able to determine correct diagnosis, based on multiple and adequate samplings.

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