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ISSN: 2155-9821

Journal of Bioprocessing & Biotechniques
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Research Article

Batch Process Modelling and Economic Evaluation of Glucuronidase Enzyme Production

M. F. Kamuri1, Dominic C. Y. Foo2 and M. Mel1*
1Bioprocess and Molecular Research Unit, Department of Biotechnology Engineering, Faculty of Engineering, International Islamic University Malaysia, P.O. Box 10, 50728 Kuala Lumpur, Malaysia
2School of Chemical and Environmental Engineering, University of Nottingham Malaysia, Broga Road, 43500 Semenyih, Selangor, Malaysia
Corresponding Author : Mel M
Department of Biotechnology Engineering
Faculty of Engineering
International Islamic University, Malaysia
Tel: 603-6196-4566
Fax: 603-6196-4442
E-mail: [email protected]
Received November 25, 2011; Accepted January 13, 2012; Published January 16, 2012
Citation: Kamuri MF, Foo DCY, Mel M (2012) Batch Process Modelling and Economic Evaluation of Glucuronidase Enzyme Production. J Bioprocess Biotechniq S4:001. doi: 10.4172/2155-9821.S4-001
Copyright: © 2012 Kamuri MF, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

β-glucuronidases enzyme is a valued product in the pharmaceutical industry. This work features the modeling and optimization of β-glucuronidases enzyme production from recombinant E. coli using SuperPro Designer v5, a commercial batch process simulator. The study focuses on designing an economically viable β- glucuronidases enzyme production process. In the base case process, an annual production of 956 batches (corresponding to 8,523 kg) of β- glucuronidases enzyme was made. Seven alternatives production schemes were further developed for increased production using batch debottlenecking strategy. The best alternative scheme was reported to achieve a product yield of 100% increment, with an annual production of 1912 batches of β- glucuronidases enzyme. Economic analysis determined that the proposed alternative scheme has an annual revenue of USD 44M, with a 15.24% gross margin and a 29.44% of return on investment. The payback period of this scheme was estimated to be less than four years.

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