alexa Bayesian Approach to Urinary ESBL-Producing Escherichia coli | OMICS International | Abstract
ISSN: 2329-6887

Journal of Pharmacovigilance
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Research Letter

Bayesian Approach to Urinary ESBL-Producing Escherichia coli

José Miguel Sahuquillo-Arce1*, Hèctor Perpiñán2, Carmen Armero2, Antonio López-Quílez2, María Selva3 and Francisco González3
1Grupo de Investigación de Infecciones Respiratorias, Hospital Universitari i Politècnic La Fe, Valencia, Spain
2Universitat de València, Valencia, Spain
3Dirección General de Salud Publica, CSISP, Valencia, Spain
Corresponding Author : José Miguel Sahuquillo-Arce
Grupo de Investigación de Infecciones Respiratorias
Hospital Universitari i Politècnic La Fe
Torre A, Bulevar Sur s/n, 46026 Valencia, Spain
Tel: 0034 963862744
Fax: 0034 961973177
E-mail: [email protected]
Received May 23, 2014; Accepted July 02, 2014; Published July 09, 2014
Citation: Sahuquillo-Arce JM, Perpiñán H, Armero C, López-Quílez A, Selva M, et al. (2014) Bayesian Approach to Urinary ESBL-Producing Escherichia coli. J Pharmacovigilance 2:133. doi: 10.4172/2329-6887.1000133
Copyright: © 2014 Sahuquillo-Arce JM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

This is a retrospective study about the prevalence of ESBL-producing Escherichia coli (EEC) in urinary specimens from patients from the Comunitat Valenciana from January 2007 to December 2008. Data were retrieved from RedMIVA, and Bayesian generalized linear mixed models were considered to study the prevalence of EEC with regard to demographical and microbiological factors. The total number of infections considered was 164,502, the amount of urinary isolates was 70,827 belonging to 49,304 different patients, and 5,161 (7.3%) of the urinary isolates were EEC. Three out of four E. coli were isolated in women (76.8%), men showed higher rates of EEC (9.7% in men vs. 6.5% in women). EEC patients were, in average, 10.8 years older, and hospitalization was more frequent (9.9% vs. 6.9%). Resistance to non-β-lactams antimicrobials was higher in EEC. The rates of ciprofloxacin and co-trimoxazol resistance in EEC were 75.5% and 52.0%, respectively, whereas it ranged between 1.4-12.4% for the rest of antimicrobials. Prior EEC infection and hospitalization were the most relevant risk factors and increased the expected EEC probability approximately 400% and 50% respectively. Other infections played an important and positive role too, Enterobacteriaceae, P. aeruginosa and other bacteria being the most relevant elements. Female gender was a protective factor and reduced the risk by approximately 25% while age was an additive risk factor. Finally, an open-access web-based software was constructed to compute the probability that an E. coli in a urinary infection be an EEC from a specific combination of risk factors. This pharmacovigilance tool should prove useful to monitor and control antimicrobial resistance spread.

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