Behavioral, Biochemical and Hematological Studies of New Synthetic Adrenergic Related Antidepressant Compound on Rats
Rana Kausar*, Nazish Waris, Asfia Raza, Zafar Saeed Saify, and Sabahat Fatima
Department of Biochemistry Federal Urdu University, Karachi, Pakistan
- *Corresponding Author:
- Kausar R
Department of Biochemistry, Federal
Urdu University, Karachi, Pakistan
E-mail: [email protected]
Received date: December 29, 2016; Accepted date: January 30, 2017; Published date: February 05, 2017
Citation: Kausar R, Waris N, Raza A, Saify ZS, Fatima S (2017) Behavioral, Biochemical and Hematological Studies of New Synthetic Adrenergic Related Antidepressant Compound on Rats. J Dev Drugs 6:168. doi:10.4172/2329-6631.1000168
Copyright: © 2017 Kausar R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The present study concerns behavioral, biochemical and hematological effects of new synthesized adrenergic related compound 1-(3, 4-dihydroxyphenyl)-2-(4-methylpiperidin-1-yl) ethan-1-one, which have similar structural activity to adrenergic receptor agonist. With intraperitoneal injection in rats, stimulatory activity in home cage, anxiolytic effect in light and dark and locomotors activity in open field were significantly increased. Biochemical effects of glucose and cholesterol were checked by kit (CHOD-PAP) method were significantly decreased. Liver enzymes including, Alkaline Phosphatase (ALP) and SGOT were markedly decreased but, Alanine aminotransferase (ALT) level was markedly increased. In hematological study, after administration of compound hemoglobin (Hb) level was significantly increased in test group of rats. Results indicate that new adrenergic related antidepressant compound not only enhanced the stimulation, locomotion and released depression and anxiety but also, this antidepressant compound show more effectiveness in depression to prevent diabetes and heart diseases.