alexa Beneficial Effects of the Free Radical Scavenger Edarav
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

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Research Article

Beneficial Effects of the Free Radical Scavenger Edaravone (Radicut) in Neurologic Diseases

Kiyoshi Kikuchi1#, Naoki Miura2#, Yoko Morimoto3, Takashi Ito4, Salunya Tancharoen5, Kei Miyata4, Chiemi Kikuchi6, Narumi Iida7, Nobuyuki Takeshige8, Hisaaki Uchikado8, Naohisa Miyagi11, Naoto Shiomi9, Terukazu Kuramoto10, Teruto Hashiguchi4, Ikuro Maruyama4, Motohiro Morioka8 and Ko-ichi Kawahara4,11*

1Department of Neurosurgery, Yame Public General Hospital, 540-2 Takatsuka, Yame 834-0034, Japan

2Veterinary Teaching Hospital and Laboratory of Veterinary Diagnostic Imaging, Faculty of Agriculture, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan

3Department of Restorative Dentistry and Endodontology, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890- 8544, Japan

4Division of Laboratory and Vascular Medicine, Field of Cardiovascular and Respiratory Disorders, Department of Advanced Therapeutics, Kagoshima University Graduate School of Medical and Dental Sciences, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan

5Department of Pharmacology, Faculty of Dentistry, Mahidol University, 6 Yothe Road, Rajthevee, Bangkok 10400, Thailand

6Department of Rehabilitation, Nishida Koutoku Hospital, 2-266 Tsuruokanishimachi, Saiki, Oita 876-0047, Japan

7Research Laboratory, Kohjin Co., Ltd., 1-6 Higashihama, Saiki, Oita 876-8580, Japan

8Department of Neurosurgery, Kurume University School of Medicine, 67 Asahimachi, Kurume 830-0011, Japan

9Department of Emergency, Saiseikai Shiga Hospital, 2-4-1 Ohashi, Rittou, Shiga 520-3046, Japan

10Department of Neurosurgery, Omuta City Hospital, 2-19-1 Takarazaka, Omuta, Fukuoka 836-8567, Japan

11Laboratory of Functional Foods, Department of Biomedical Engineering Osaka Institute of Technology, 5-16-1 Omiya, Asahi Ward, Osaka 535-8585, Japan

#These Authors are Contributed equally

Corresponding Author:
Dr. Ko-ichi Kawahara PhD
Division of Laboratory and Vascular Medicine
Department of Advanced Therapeutics
Kagoshima University Graduate School of Medical and Dental Sciences 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan
Tel: +81-99-275-5437
Fax: +81- 99-275-2629
E-mail: [email protected]

Received date: May 11, 2011; Accepted date: June 30, 2011; Published date: September 20, 2011

Citation: Kikuchi K, Miura N, Morimoto Y, Ito T, Tancharoen S, et al. (2011) Beneficial Effects of the Free Radical Scavenger Edaravone (Radicut) in Neurologic Diseases. J Neurol Neurophysiol S1. doi:10.4172/2155-9562.S1-001

Copyright: © 2011 Kikuchi K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Free radicals play major roles in the pathogenesis of many diseases, including neurologic diseases, making them an attractive target for therapeutic intervention. Several free radical scavengers have been developed, and some have progressed to clinical trials for the treatment of ischemic stroke. One such scavenger, edaravone is currently used to treat patients who present within 24 h of an attack. Edaravone can diffuse into many affected organs. Edaravone also exerts protective effects against brain and spinal cord injuries. Beyond its direct free radical scavenging effect, edaravone has anti-apoptotic and anti-inflammatory effects in various diseases. Here, we critically review the literature on experimental animal model and clinical studies of edaravone efficacy, and examine whether it should be considered a candidate for worldwide development. Edaravone has proven safe during 10 years of use as a free radical scavenger to treat ischemic stroke. In addition to ischemic stroke treatment, animal data suggest that edaravone may be an effective treatment option for several neurologic diseases, but additional clinical trials are necessary to verify its efficacy.

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