alexa Berberine: A Medicinal Compound for the Treatment of Ba
ISSN: 2327-5073

Clinical Microbiology: Open Access
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Review Article

Berberine: A Medicinal Compound for the Treatment of Bacterial Infections

Ming Chu1#, Rong-xin Xiao1#, Yi-nan Yin1, Xi Wang1, Zheng-yun Chu2, Ming-bo Zhang2, Ran Ding2 and Yue-dan Wang1*

1Department of Immunology, School of Basic Medical Sciences, Peking University, Beijing 100191, China

2Pharmacy Departments, Liao Ning University of Traditional Chinese Medicine, Liao Ning 116600, China

#Equal Contribution

*Corresponding Author:
Yue-dan Wang
Department of Immunology
School of Basic Medical Sciences
Peking University, Xueyuan Road
Haidian District, Beijing 100191, China
Tel: 86-82801388
Fax: 86-82801388
E-mail: [email protected]

Received Date: March 27, 2014; Accepted Date: May 20, 2014; Published Date: May 28, 2014

Citation: Chu M, Xiao R, Yin Y, Wang X, Chu Z, et al. (2014) Berberine: A Medicinal Compound for the Treatment of Bacterial Infections. Clin Microbial 3:150. doi: 10.4172/2327-5073.1000150

Copyright: © 2014 Chu M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Berberine is an isoquinoline alkaloid mainly extracted from Rhizoma Coptidis, which is an efficient therapeutic agent to combat bacterial infections. However, bioactive assay manifested that berberine exhibited poor effect on antibacterial properties. In the present paper, we reviewed the multiple activities of berberine, including inhibition of biofilm formation, anti-inflammation effect, and clinical trials, which indicate the possible mechanism of berberine in the treatment of bacterial infections.


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