Beware of Paracetamol Toxicity
Vidhya Malar HL* and S Mary Mettilda Bai
P.G and Research Department of Zoology, Holy Cross College, Nagercoil- 629 004, Tamil Nadu, India
- *Corresponding Author:
- Vidhya Malar HL
P.G and Research Department of Zoology
Holy Cross College
Nagercoil- 629 004, Tamil Nadu, India
E-mail: [email protected]
Received date: August 14, 2012; Accepted date: September 13, 2012; Published date: September 15, 2012
Citation: Vidhya Malar HL, Mary Mettilda Bai S (2012) Beware of Paracetamol Toxicity. J Clinic Toxicol 2:142. doi: 10.4172/2161-0495.1000142
Copyright: © 2012 Vidhya Malar HL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The Effect of Paracetamol mechanism by which it works, metabolism, recommended doses, toxic dosage are discussed with study reports in this paper. Paracetamol shows some life threatening effects like Liver damage which in turn leads to live failure and death. Though it reduces fever and pain, it is found highly toxic. The mechanism by which Paracetamol reduces fever and pain is still not known. On metabolism, Paracetamol is converted to a metabolite which is very toxic to liver cells. In recommended doses (1-2 g/day), Paracetamol does not irritate stomach lining, kidney cells and liver cells. Studies reported that high dosage (>2 g/day), resulted in Gastrointestinal complications, abnormal Kidney function, Liver damage.