alexa Bilateral Anotia with Exposure to Retinoic Acid during
ISSN: 2165-7920

Journal of Clinical Case Reports
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Case Report

Bilateral Anotia with Exposure to Retinoic Acid during Pregnancy

Atis A*, Acar D, Talmac M, Polat Ä°, Yilmaz E and Gedikbasi A
Kanuni Sultan Suleyman Training & Research Hospital, Perinatology, Istanbul, Turkey
Corresponding Author : Alev Atis
Kanuni Sultan Suleyman Training & Research Hospital
Perinatology, Istanbul, Turkey
Tel: (212)373-5000
E-mail: [email protected]
Received January 11, 2014; Accepted March 15, 2014; Published March 17, 2014
Citation: Atis A, Acar D, Talmac M, Polat I, Yilmaz E, et al. (2014) Bilateral Anotia with Exposure to Retinoic Acid during Pregnancy. J Clin Case Rep 4:353. doi:10.4172/2165-7920.1000353
Copyright: © 2014 Atis A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Isotretinoin (13-cis retinoic acid) is the most potent known inhibitor of sebum production and is by far one of the most effective antiacne medications for the treatment of severe and scarring acne, but it has been shown to be teratogenic when used during pregnancy. The risk of malformations in the population is 3-5%, but it has been reported to increase to almost 30% in women exposed to isotretinoin.


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