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Bioactive Glass-Green and Red Propolis Association: Antimicrobial Activity Against Oral Pathogen Bacteria | OMICS International | Abstract
ISSN: 2329-6836

Natural Products Chemistry & Research
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Research Article

Bioactive Glass-Green and Red Propolis Association: Antimicrobial Activity Against Oral Pathogen Bacteria

Walison A Vasconcelos1, Neilor M A Braga2, Vitor R Chitarra3, Vagner R Santos3*, Ângela L Andrade4
and Rosana Z Domingues5
1Department of Restorative Dentistry, Dentistry School, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
2Department of Restorative Dentistry, Dentistry School, Estadual University of Montes Claros, Montes Claros, MG, Brazil
3Laboratory of Microbiology and Biomaterials, Dentistry School, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
4Department de Química-ICE, Federal University of Ouro Preto, Ouro Preto, MG, Brazil
5Department de Química-ICEX, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil
Corresponding Author : Vagner Rodrigues Santos
Department Oral Clinical, Oral Pathology
Oral Surgery, Faculdade de Odontologia
Universidade Federal de Minas Gerais
Avenida Antonio Carlos 6627 – Campus Pampulha
Belo Horizonte, Minas Gerais, Brazil, CEP 31270-901
Tel: +55-31-3409-2497
Fax: +55-31-3409-2430
E-mail: [email protected]
Received September 10, 2014; Accepted October 15, 2014; Published October 17, 2014
Citation: Vasconcelos WA, Braga NMA, Chitarra VR, Santos VR, Andrade ÂL (2014) Bioactive Glass-Green and Red Propolis Association: Antimicrobial Activity Against Oral Pathogen Bacteria. Nat Prod Chem Res 2:154. doi:10.4172/2329-6836.1000154
Copyright: © 2014 Vasconcelos WA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Bioactive glasses were studied as potential drug delivery candidates for the incorporation and release of natural products. In light of these studies, the antimicrobial activity of a new formulation containing propolis was evaluated. Susceptibility of oral pathogens microorganisms were evaluated using the CLSI standard MIC, MBC and agar diffusion method with Brazilian green (BGP) and red (BRP) propolis extracts isolated and associated with bioglass (BGGP and BGRP). Isolated Bioglass (BG), Tetracycline (TT) and Ethanol (ET) were the controls. Results data were expressed as M ± SD. Significant differences between microorganisms treated groups antimicrobial assays were analyzed by Student’s-test (significance at) using the Origin 6.0 program. All tested bacteria were susceptible to bioglassincorporated green and red propolis. The new formulation was effective for inhibiting the in vitro microorganisms growth after 24 and 48 hours at 37°C in an atmosphere specific to each microorganism. Red propolis being more active than the green one. Propolis incorporated into bioglass did not lose its antimicrobial properties. The positive results suggest that propolis in this sustained release formulation should be further tested as an alternative therapy against infectious agents of the oral cavity.

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