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Bioceramics Development and Applications
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Research Article

Bioactivity and Osteoconductivity of Biphasic Calcium Phosphates

Jung Sang Cho1, Chong-Pyong Chung3, and Sang-Hoon Rhee1,2*,

1Interdisciplinary Program of Bioengineering, College of Engineering, Seoul National University, Seoul 152-742, South Korea

2Department of Dental Biomaterials Science, School of Dentistry, Seoul National University, Seoul 110-749, South Korea

3Department of Periodontology, School of Dentistry, Seoul National University, Seoul 110-749, South Korea

Corresponding Author:
Sang-Hoon Rhee
Interdisciplinary Program of Bioengineering
College of Engineering, Seoul National University
Seoul 152-742, South Korea
Email: [email protected]

Received date: 11 November 2010; Accepted date: 02 December 2010

Abstract

Bioactivity and osteoconductivity of calcium phosphates as a function of ?-tricalcium phosphate contents, that is, biodegradability, were investigated. Three calcium phosphates, pure hydroxyapatite, biphasic calcium phosphates with different mixing ratios between hydroxyapatite, and ?-tricalcium phosphate (60HAp:40?- TCP and 40HAp:60?-TCP in wt.%), were synthesized through the precipitation method using calcium hydroxide and phosphoric acid as starting reactants. After drying, they were sintered at 1100 °C for 3 hours, and then bioactivity and osteoconductivity tests were carried out in simulated body fluid (SBF) and calvarial defect of New Zealand white rabbits, respectively. SBF exposure resulted in the deposition of a layer of carbonate apatite crystals on the surfaces of bicalcium phosphates but not on the hydroxyapatite. New bone forming capacity of the biphasic calcium phosphate with 60HAp:40?-TCP granules was the best, whereas that of the pure HAp was the worst. To this end, it can be concluded that the calcium phosphate with moderate biodegradability is good for producing good osteoconductivity.

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