alexa Bioassay-guided Isolation of New Antitumor Agent from Ficus faveolata (Wall. ex Miq.)
ISSN: 1948-5956

Journal of Cancer Science & Therapy
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Research Article

Bioassay-guided Isolation of New Antitumor Agent from Ficus faveolata (Wall. ex Miq.)

Ala Ud Din1*, Ghias Uddin2, Nusrat Hussain3, Inamullah Khan4, Anwar Ali Shad5, Muhammad Iqbal Choudhary3

1Deparment of Chemistry, Bacha Khan University Charsadda 24420, Pakistan

2Center for Phytomedicine and Medicinal Organic Chemistry, Institute of Chemical Sciences, University of Peshawar, Pakistan

3HEJ Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Pakista

4Department of Pharmacy, University of Peshawar, Pakistan

5Department of Agricultural Chemistry, KPK Agricultural University, Peshawar, Pakistan

*Corresponding Author:
Ala Ud Din
Deparment of Chemistry
Bacha Khan University Charsadda 24420, Pakistan
Tel: +92-939540156
E-mail: [email protected]; [email protected]

Received Date: October 03, 2013; Accepted Date: November 18, 2013; Published Date: November 23, 2013

Citation: Din AU, Uddin G, Hussain N, Khan A, Khan I, et al. (2013) Bioassayguided Isolation of New Antitumor Agent from Ficus faveolata (Wall. ex Miq.). J Cancer Sci Ther 5:404-408. doi: 10.4172/1948-5956.1000233

Copyright: © 2013 Din AU, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Ficus species have been used in both Ayurvedic and Traditional Chinese Medicine (TCM); however the medicinal uses of these species are widely found and originated in Middle East. The phytochemical study of Ficus foveolata was under taken with small scale extraction of stem (300 g) for cytotoxic screening and dereplication purpose. The crude methanolic extract of Ficus was partitioned into different fractions of hexane, dichloromethane and methanol. All the five fractions FA, FB, FC, FD and FE were screened for their anti-proliferative effect in the disk diffusion assay (In vitro) against six cancer cell lines. The bioassay-guided isolation of a new antitumor agent (Ficusonolide; 3α-hydroxylean-12-en-29, 19α-olide (1)) was carried out from the methanolic extract (FB) of Ficus faveolata. Its structure was elucidated on the basis of extensive spectroscopic techniques (IR, MS and NMR). The pure compound 1 was evaluated against twelve cell cancer lines for the determination of its antiproliferative potency. In disk diffusion assay the dichloromethane fraction (FB) showed excellent activity at very low concentration. The compound 1 exhibited strong and selective activity against two cancer cell lines: H116 (Human colon adenocarcinoma) and H125 (Human lung adenocarcinoma) with the IC50=7.8 μg/ml and 11.0 μg/ ml respectively. The selectivity and potency of the pure compound 1 was in concordance with the activity profile of the fraction FB and ethno-medicinal uses of this plant. This small project on local medicinal plants has opened new vista for future research work on indigenous medicinal plants. The compound 1 can be used a template compound for further studies, as a chemotherapeutic agents against cancer.

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