alexa Bioavailability of Strontium Ions from Bioactive Glasses In Vivo: A Micro-PIXE Study of Trace Elements at the Bone Interface | OMICS International | Abstract

Bioceramics Development and Applications
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Research Article

Bioavailability of Strontium Ions from Bioactive Glasses In Vivo: A Micro-PIXE Study of Trace Elements at the Bone Interface

Jonathan Lao1*, Joséphine Lacroix1, Johnny Nohra2-5, Nada Naaman5, Jean-Michel Sautier2-4 and Édouard Jallot1

1Clermont Université, Université Blaise Pascal, CNRS/IN2P3, Laboratoire de Physique Corpusculaire, BP 80026, 63171 Aubière Cedex, France

2INSERM, U872, Eq.5, Laboratoire de Physiopathologie Orale et Moléculaire, Paris, F- 75006, France

3Centre de Recherche des Cordeliers, Université Pierre et Marie Curie, UMR S 872, Paris, F- 75006, France

4Université Paris Diderot, Paris 7, UFR d'Odontologie, Paris, France

5Department of Periodontology, Laboratory of Calcified Tissue, School of Medical Dentistry, Saint-Joseph University, Beirut, Lebanon

Corresponding Author:
Jonathan Lao
Clermont Université, Université Blaise Pascal
CNRS/IN2P3, Laboratoire de Physique Corpusculaire
BP 80026, 63171 Aubière Cedex, France
E-mail: [email protected]

Received date: June 08, 2013; Accepted date: July 22, 2013; Published date: August 23, 2013

Citation: Lao J, Lacroix J, Nohra J, Naaman N, Sautier JM, et al. (2013) Bioavailability of Strontium Ions from Bioactive Glasses In Vivo: A Micro-PIXE Study of Trace Elements at the Bone Interface. Bioceram Dev Appl S1:004. doi:10.4172/2090-5025.S1-004

Copyright: © 2013 Lao J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Studying the local release of strontium traces in vivo is of key interest, but calls for highly sensitive techniques besides providing an excellent (micronic) spatial resolution. In this context nuclear microprobes such as the PIXE (Particle-Induced X-ray Emission) technique, appear as powerful tools of investigation. Here, the in vivo behaviour of a Sr-delivering bioactive glass has been investigated through micro-PIXE analyses in connection with histological studies. New bone formation is observed after 6 weeks of implantation in rabbit femoral condyle. Interestingly, Sr traces are detected over a large area at the site of implantation, demonstrating the efficient release of Sr osteo inductive ions from the glass and their diffusion over several ten microns through the tissues. From its inorganic composition and content in traces of interest such as Zn, neo formed bone seems of higher quality for Sr-delivering particles compared to Sr-free particles, evidencing the positive effect of Sr in vivo.


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