Biochemical and Pharmacological Effects of Mitoxantrone and Acetyl-LCarnitine in Mice with a Solid Form of Ehrlich TumourNiang M1*, Soukup T2 , Bukac J3, Siman P1, Stoklasová A1, and Cerman J1
- *Corresponding Author:
- Niang M
Department of Medical Biochemistry
Charles University in Prague
Faculty of medicine: Zborovská 2089
500 09 Hradec Králové.Czech Republic
Tel: +420 495816452
E-mail : [email protected]
Received Date: November 10, 2015 Accepted Date: December 19, 2015 Published Date: December 24, 2015
Citation: Niang M, Soukup T , Bukac J, Siman P, Stoklasová A, and Cerman J (2015) Biochemical and Pharmacological Effects of Mitoxantrone and Acetyl-L-Carnitine in Mice with a Solid Form of Ehrlich Tumour. Chemo Open Access 5:180. doi: 10.4172/2167-7700.1000180
Copyright: © 2015, Niang M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Since the beginning of 1990, our Laboratories begun a series of in vivo experimental studies to evaluate the effect of carnitine derivatives on the antineoplastic activity of mitoxantrone (MX) a dihydroxyanthracene derivative on various animal models of cancer The objective was to determine pre-clinically whether carnitine and its acyl-derivatives in combination with mitoxantrone could be found to be good candidates to ameliorate host’s metabolic response to tumour processes, and therefore could play a valuable role in the field of cancer treatment.