alexa Biochemical and Pharmacological Effects of Mitoxantrone
ISSN: 2167-7700

Chemotherapy: Open Access
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Commentary

Biochemical and Pharmacological Effects of Mitoxantrone and Acetyl-LCarnitine in Mice with a Solid Form of Ehrlich Tumour

Niang M1*, Soukup T2 , Bukac J3, Siman P1, Stoklasová A1, and Cerman J1

1Department of Medical Biochemistry, Charles University in Prague, Czech Republic

2Department of Histology and Embryology, Charles University in Prague, Czech Republic

3Department of Medical Biophysics, Charles University in Prague, Czech Republic

*Corresponding Author:
Niang M
Department of Medical Biochemistry
Charles University in Prague
Faculty of medicine: Zborovská 2089
500 09 Hradec Králové.Czech Republic
Tel: +420 495816452
E-mail : [email protected]

Received Date: November 10, 2015 Accepted Date: December 19, 2015 Published Date: December 24, 2015

Citation: Niang M, Soukup T , Bukac J, Siman P, Stoklasová A, and Cerman J (2015) Biochemical and Pharmacological Effects of Mitoxantrone and Acetyl-L-Carnitine in Mice with a Solid Form of Ehrlich Tumour. Chemo Open Access 5:180. doi: 10.4172/2167-7700.1000180

Copyright: © 2015, Niang M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Since the beginning of 1990, our Laboratories begun a series of in vivo experimental studies to evaluate the effect of carnitine derivatives on the antineoplastic activity of mitoxantrone (MX) a dihydroxyanthracene derivative on various animal models of cancer The objective was to determine pre-clinically whether carnitine and its acyl-derivatives in combination with mitoxantrone could be found to be good candidates to ameliorate host’s metabolic response to tumour processes, and therefore could play a valuable role in the field of cancer treatment.

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