alexa Biochemical Structure and Functions of the Lumbar Disc after an Autologous Chondrocyte Transplantation (ACT) Evaluated by Studies of Two Operated Cases of Repeated Disc Herniation
ISSN: 2165-7939

Journal of Spine
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Research Article

Biochemical Structure and Functions of the Lumbar Disc after an Autologous Chondrocyte Transplantation (ACT) Evaluated by Studies of Two Operated Cases of Repeated Disc Herniation

Abaaslam F1,2, Marszałek P2, Głowacki M1, Włuka A1, Sierzputowski T2 and Czernicki Z1,2*
1M. Mossakowski Institute of Experimental and Clinical Medicine, Polish Academy of Sciences, Warsaw, Poland
2Department of Neurosurgery, 2nd Faculty of Medicine, Medical University of Warsaw, Poland
Corresponding Author : Zbigniew Czernicki
Mossakowski Medical Research Centre
Polish Academy of Sciences, Department of Neurosurgery
2nd Faculty of Medicine, Medical University of Warsaw, Poland
Tel: +48 22 552 00 00
E-mail: [email protected]
Received: October 10, 2015; Accepted: December 17, 2015; Published: December 19, 2015
Citation: Abaaslam F, Marszałek P, Głowacki M, Włuka A, Sierzputowski T, et al. (2015) Biochemical Structure and Functions of the Lumbar Disc after an Autologous Chondrocyte Transplantation (ACT) Evaluated by Studies of Two Operated Cases of Repeated Disc Herniation. J Spine 4:276.doi:10.4172/2165-7939.1000276
Copyright: © 2015 Abaaslam F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Transplantation of autologous chondrocytes obtained from cellular culture constitutes one of the methods of the biological treatment of the degenerative disc disease (DDD). The study covered a group of 50 patients operated on for single-level lumbar discopathy in whom material for autologous chondrocyte culture was sampled from a removed fragment of an intervertebral disc. The chondrocytes obtained from the culture were next implanted into the pre-operated space with the use of the percutaneous method, the implantation being followed by a radiological and clinical evaluation. In two cases a repeated prolapse of a nucleus pulposus fragment was reported after an earlier transplantation. The patients were operated on again. The material obtained from the recurred nucleus pulposus hernia allowed for a biological evaluation of the effect of the transplantation on the structure of the intervertebral disc with a light and confocal microscope. The examination showed good integration of the transplanted cells with the cellular matrix and their correct production activity in the form of the generation of typical matrix components – type I, II, III, IX collagen, proteoglycans and aggrecan as well as type IV collagen, atypical for the matrix, the presence of which is a subject of further research works.

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