alexa Biocompatibility of a Synthetic Biopolymer for the Trea
ISSN: 2155-9570

Journal of Clinical & Experimental Ophthalmology
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Research Article

Biocompatibility of a Synthetic Biopolymer for the Treatment of Rhegmatogenous Retinal Detachment

Shanta Sarfare1*, Yann Dacquay1, Syed Askari2, Steven Nusinowitz1 and Jean-Pierre Hubschman1
1Jules Stein Eye Institute, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California 90095, USA
2Medicus Biosciences, 2528 Qume Drive, Unit 1, San José, California 95131, USA
Corresponding Author : Shanta Sarfare
Ora, Inc., 300 Brickstone Square
Andover, Massachusetts, USA
Tel: 978-685-8900 extension 9532
Fax: 978-689-0020
E-mail: [email protected]
Received August 28, 2015; Accepted September 10, 2015; Published September 14, 2015
Citation: Sarfare S, Dacquay Y, Askari S, Nusinowitz S, Hubschman JP (2015) Biocompatibility of a Synthetic Biopolymer for the Treatment of Rhegmatogenous Retinal Detachment. J Clin Exp Ophthalmol 6:475. doi: 10.4172/2155-9570.1000475
Copyright: © 2015 Sarfare S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Objective: The aim of this study is to evaluate the retinal safety and toxicity of a novel synthetic biopolymer to be used as a patch to treat rhegmatogenous retinal detachment. Methods: Thirty one adult wild type albino mice were divided in 2 groups. In Group A (n=9) 0.2 μl balanced salt solution (BSS) and in Group B (n=22), 0.2 μl biopolymer was injected in the subretinal space. Trans-scleral subretinal injection was performed in one eye and the fellow eye was used as control. In both groups, in vivo color fundus photography, electroretinogram (ERG), spectral domain optical coherence tomography (SD-OCT) were performed before injection and at days 7 and 14 post-intervention. Histological analysis was performed following euthanization at days 1, 7 and 21 post-injection. Results: The biopolymer was visualized in the subretinal space in vivo by SD-OCT and post-life by histology up to 1 week after the injection. There were no significant differences in ERG parameters between the two groups at 1 and 2 weeks post-injection. Minimal inflammatory response and loss of photoreceptor cells was only observed in the immediate proximity of the site of scleral perforation, which was similar in both groups. Overall integrity of the outer, inner retina and retinal pigment epithelial (RPE) layers was unaffected by the presence of the biopolymer in the subretinal space. Conclusions: Functional and histological evaluation suggests that the synthetic biopolymer is non-inflammatory and non-toxic to the eye. It may represent a safe therapeutic agent in the future, for the treatment of rhegmatogenous retinal detachment.


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