alexa Bioengineered Skin: The Self-Assembly Approach
ISSN: 2157-7552

Journal of Tissue Science & Engineering
Open Access

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Research Article

Bioengineered Skin: The Self-Assembly Approach

Jessica Jean1,2, Martha Estrella Garcia-Pérez1,2 and Roxane Pouliot1,2*

1Centre LOEX de l’Université Laval, Génie tissulaire et régénération, LOEX - Centre de recherche FRSQ du Centre hospitalier affilié universitaire de Québec, Aile-R, 1401 18e rue, Québec, Québec, Canada, G1J 1Z4

2Faculté de Pharmacie, Université Laval, Québec, Québec, Canada, G1V 0A6

Corresponding Author:
Roxane Pouliot, Ph.D.
Centre LOEX de l’Université Laval
Génie Tissulaire et régénération
LOEX - Centre de recherche FRSQ du
Centre hospitalier affilié universitaire de Québec
Aile-R, 1401 18e rue, Québec
Québec, Canada, G1J 1Z4
Tel: (1) 418-990-8255 ext. 1706
Fax: (1) 418-990-8248
E-mail: [email protected]

Received date: June 15, 2011; Accepted date: October 19, 2011; Published date: October 21, 2011

Citation:Jean J, Garcia-Pérez ME, Pouliot R (2011) Bioengineered Skin: The Self- Assembly Approach. J Tissue Sci Eng S5:001. doi:10.4172/2157-7552.S5-001

Copyright: © 2011 Jean J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Tissue-engineered skin substitutes represent an innovative therapeutic option for the treatment of burns and
skin ulcers as well as a powerful tool for fundamental research. To be efficient, in vitro skin substitutes must closely
mimic human skin structures and exogenous material has to be reduced as much as possible. The self-assembly
approach is based on the capacity of fibroblasts to create their own extracellular matrix in vitro, which allows the
production of cell sheets that are easy to handle. Therefore, a skin substitute devoid of exogenous extracellular
matrix proteins and synthetic material is produced, which demonstrates many histological, physico-chemical and
mechanical characteristics found in normal human skin in vivo. A particularity of this approach is the possibility to
add various other cell types (keratinocytes, melanocytes, adipocytes, endothelial and immunological cells, etc.)
according to needs. Furthermore, pathological cells (hypertrophic scar, sclerodermic, tumoral and psoriatic cells)
can be used for the production of pathological skin substitutes. The development of these models represents a key
component in the fight against such diseases because they can lead to a better understanding of the pathology
and to the development of new pharmaceutical therapies.This review will present the need for tissue-engineered
skin substitutes, the implication of tissue engineering in the cutaneous field (basic and applied research), the selfassembly
approach and its characteristics as well as the actual state of research on healthy and pathological selfassembled
skin models.

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