alexa Biological and Molecular Diversity in Telomerase: Chara
ISSN: 2168-9296

Cell & Developmental Biology
Open Access

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Review Article

Biological and Molecular Diversity in Telomerase: Characteristics of hTERT in Human, Vertebrates and Yeast

Elahe Abdollahi and Parvin Mehdipour*
Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
*Corresponding Author : Parvin Mehdipour
Department of Medical Genetics, School of Medicine
Tehran University of Medical Sciences, Tehran, Iran
Tel: 989121276725
E-mail: [email protected]
Received: March 11, 2016 Accepted: April 12, 2016 Published: April 20, 2016
Citation: Abdollahi E, Mehdipour P (2016) Biological and Molecular Diversity in Telomerase: Characteristics of hTERT in Human, Vertebrates and Yeast. Cell Dev Biol 5:170. doi:10.4172/2168-9296.1000170
Copyright: © 2016 Abdollahi E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

hTERT (human telomerase reverse transcriptase) is the catalytic subunit of telomerase enzyme, and is essential for its functions. The aim of this review was to compare the TERT in human and other species including microorganism, vertebrates and mammals, in terms of its functions and regulation. According to literature, the catalytic subunit of telomerase in animals contains many conserved domains and residues, which have crucial roles in its functions. Moreover, the structure and biology of human telomerase seem to be more similar to that of dog compared other animals. Thus interestingly, unlike the mouse that is seemingly not a proper model for evaluation of telomerase activity and its regulation, dog may be an appropriate model for the experimental investigations of telomerase function and therapeutic strategies in cancer studies.

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