alexa Biological Effect of Calcium Phosphate Bioceramics Micr

Bioceramics Development and Applications
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Research Article

Biological Effect of Calcium Phosphate Bioceramics Microstructure

Serge Baroth1,2* and Guy Daculsi1

1INSERM, Universit de Nantes, UMR U791, Facult de Chirurgie Dentaire, Place Alexis Ricordeau, 44042 Nantes Cedex 01, France

2Biomatlante SAS, ZAC des 4 Nations, 5 rue Edouard Belin, 44360 Vigneux de Bretagne, France

Corresponding Author:
Serge Baroth
INSERM, Universit de Nantes
UMR U791, Facult de Chirurgie Dentaire
Place Alexis Ricordeau, 44042 Nantes Cedex 01, France
Email: [email protected]

Received date: 11 November 2010; Accepted date: 02 December 2010



Understanding of interactions between cells and biomaterials is a huge parameter for improving tissue engineering and regenerative medical fields. Many different materials have already been tested (including calcium phosphate ceramics) and it has been established that surface characteristic is a parameter that influences cell responses. The aim of this work was to characterize calcium phosphate discs containing various ratios of HA/?-TCP and specific microstructure. First results show that chemical composition and compression parameters modify surface materials. Secondly, cells were cultured (osteoblast-like cells MC3T3- E1) and morphology, viability, and differentiation were studied. SEM observations, mitochondrial (MTS assay), and alkaline phosphatase activity (ALP) measurements showed that osteoblasts have better viability and a higher rate of differentiation when cultured on dense surface compared to porous surface. The aim of this experiment was to contribute to the knowledge of interactions between osteoblast-like cells and microstructured calcium phosphate bioceramics pellets.


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