Biological Evaluation of 2, 5-Di (4 Aryloylaryloxy Methyl) - 1, 3, 4-Oxadiazoles Derivatives as Antimicrobial Agents
- *Corresponding Author:
- Yasser Hussein Eissa Mohammed
Department of Biochemistry, Applied Science College
University of Hajja, Yemen
E-mail: [email protected] (or) [email protected]
Received Date: March 03, 2017 Accepted Date: April 06, 2017 Published Date: April 10, 2017
Citation: Eissa Mohammed YH, Gurupadaswamy HD, Khanum SA (2017) Biological Evaluation of 2, 5-Di (4 Aryloylaryloxy Methyl) - 1, 3, 4-Oxadiazoles Derivatives as Antimicrobial Agents. Med Chem (Los Angeles) 7: 837-843. doi: 10.4172/2161- 0444.1000438
Copyright: © 2017 Eissa Mohammed YH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A series of potential biologically active substituted 2,5-di(4 aryloylaryloxymethyl)-1,3,4-oxadiazoles 9a-j were evaluated for its potential antimicrobial activity comparing with the standard drugs-Streptomycin and Ketoconazole respectively. Compound 9a with fluoro group exhibited highest activity against both gram-positive and gramnegative bacteria. Compounds 9a with fluoro group and 9c with fluoro and bromo showed good activity against antifungal activities.