alexa Biological Evaluation of 2, 5-Di (4 Aryloylaryloxy Methyl) - 1, 3, 4-Oxadiazoles Derivatives as Antimicrobial Agents
ISSN: 2161-0444

Medicinal Chemistry
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Research Article

Biological Evaluation of 2, 5-Di (4 Aryloylaryloxy Methyl) - 1, 3, 4-Oxadiazoles Derivatives as Antimicrobial Agents

Yasser Hussein Eissa Mohammed1,2*, Gurupadaswamy HD1 and Shaukath Ara Khanum1

1Department of Chemistry, Yuvaraja’s College, University of Mysore, Mysore, Karnataka, India

2Department of Biochemistry, Applied Science College, University of Hajja, Yemen

*Corresponding Author:
Yasser Hussein Eissa Mohammed
Department of Biochemistry, Applied Science College
University of Hajja, Yemen
Tel: 0096773305594
E-mail: issayasser@gmail.com (or) yasserhussein@ycm.uni-mysore.ac.in

Received Date: March 03, 2017 Accepted Date: April 06, 2017 Published Date: April 10, 2017

Citation: Eissa Mohammed YH, Gurupadaswamy HD, Khanum SA (2017) Biological Evaluation of 2, 5-Di (4 Aryloylaryloxy Methyl) - 1, 3, 4-Oxadiazoles Derivatives as Antimicrobial Agents. Med Chem (Los Angeles) 7: 837-843. doi: 10.4172/2161- 0444.1000438

Copyright: © 2017 Eissa Mohammed YH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

A series of potential biologically active substituted 2,5-di(4 aryloylaryloxymethyl)-1,3,4-oxadiazoles 9a-j were evaluated for its potential antimicrobial activity comparing with the standard drugs-Streptomycin and Ketoconazole respectively. Compound 9a with fluoro group exhibited highest activity against both gram-positive and gramnegative bacteria. Compounds 9a with fluoro group and 9c with fluoro and bromo showed good activity against antifungal activities.

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