Biological Markers Changes at the Very Early Stage of Ageing (60-65 Years). Is There a Gender-Related Effect?Daniela Teixeira1, Mayari E Ishimura1, Ieda M Longo-Maugeri1, Maria L Lebrão2, Yeda AO Duarte2, and Valquiria Bueno1*
- *Corresponding Author:
- Bueno V
Department of Microbiology
Immunology, and Parasitology
UNIFESP Federal University of São Paulo
Rua Botucatu 862, 04023-900 Sao Paulo, Brazil
Tel: 5511 55496073
Fax: 55 1155496073
Email: [email protected]
Received date: January 07, 2015; Accepted date: April 01, 2015; Published date:April 09, 2015
Citation: Daniela Teixeira, Mayari E Ishimura, Ieda M Longo-Maugeri, Maria L Lebrão, Yeda AO Duarte and Valquiria Bueno (2015) Biological Markers Changes at the Very Early Stage of Ageing (60-65 Years). Is There a Gender-Related Effect?. Aging Sci 3:132. doi: 10.4172/2329-8847.1000132
Copyright: © 2015 Teixeira D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Aging has been associated with progressive molecular and structural changes causing loss of function in several organs. There is a general hypothesis that very old individuals suffer profound modifications where different domains (immune, metabolic and cognitive) loose the tight functional interconnection present in younger bodies. However, it is not clear how this interconnection is affected at the very early stage of ageing and whether gender plays a role. Therefore, our aim was to evaluate some biological markers in non-institutionalized “healthy individuals” at the very early stage of aging (60 to 65 years old, female and male). Blood was collected and serum creatinine, albumin and glucose were measured. In addition, we evaluated these individuals for lymphocytes phenotype (T CD4+, T CD8+, CD19+) by flow cytometry in peripheral mononuclear blood cells. It was observed that at the early stage of ageing male present higher creatinine and albumin serum levels compared to female. In addition, male had higher percentages of effector memory CD4+ and CD8+ T cells and lower percentages of naive CD8+ T cells. No differences were observed for B cells. These findings suggest that metabolic functions and immune system are compromised in male individuals at the very early stage of ageing and thus gender differences should be considered for the design of new therapies to the elderly.