Biology of the B-Type Natriuretic Peptide: Structure, Synthesis and ProcessingGábor Szabó*
Department of Obstetrics and Gynecology, Semmelweis University, Baross u. 27, Budapest, Hungary
- *Corresponding Author:
- Dr. Gábor Szabó
Department of Obstetrics and Gynecology
Baross u. 27, Budapest
E-mail: [email protected].sote.hu
Received Date: November 17, 2012; Accepted Date: November 19, 2012; Published Date: November 21, 2012
Citation: Szabó G (2012) Biology of the B-Type Natriuretic Peptide: Structure, Synthesis and Processing. Biochem Anal Biochem 1:e129. doi: doi: 10.4172/2161-1009.1000e129
Copyright: © 2012 Szabó G. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
In 1988, a new member of the natriuretic peptide family was isolated. BNP is a circulating hormone playing key role, together with the sympathetic nervous system and other hormones like an endogeneous system in the regulation of the body fluid homeostasis and blood pressure. The function and physiological role of B type natriuretic peptide is pleiotropic. BNP is synthesized from polypeptide precursors. BNP and N-terminal proBNP are the products of pro BNP processing. In many cardiovascular diseases natriuretic peptides serve not only as marker for diagnosis and prognosis but they have therapeutic importance. In the last years the potential use of the elevated BNP levels for diagnosis of pre-eclampsia was examined. In our review, we discuss the current understanding of molecular biology, biochemistry and clinical relevance of natriuretic peptides.