alexa Biomarkers for the Detection of Pre-Cancerous Stage of Cervical Dysplasia | OMICS International | Abstract

Journal of Molecular Biomarkers & Diagnosis
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Review Article

Biomarkers for the Detection of Pre-Cancerous Stage of Cervical Dysplasia

Paz Elia1, Stella Raizelman1, Esti Katorza1,2, Yosef Matana1, Offer Zeiri3, Zvi Boger1,4, Manuela Cervelli5, Paolo Mariotini5, Cristina Vallone6, Fabrizio Signore6 and Yehuda Zeiri1,7*

1Department of Biomedical Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel

2Division of Radiotoxicology, Nuclear Research Center - Negev, Beer-Sheva, Israel

3Department of Chemistry, Ben-Gurion University of the Negev, Beer-Sheva, Israel

4OPTIMAL - Industrial Neural Systems Ltd., Beer-Sheva, Israel

5Department of Sciences, University “Roma Tre”, Rome, Italy

6Department of Gynecology, Breast Surgery and Pathology, San Camillo-Forlanini Hospital, Rome, Italy

7Division of Chemistry, Nuclear Research Center - Negev, Beer-Sheva, Israel

*Corresponding Author:
Yehuda Zeiri
Biomedical Engineering
Ben-Gurion University of the Negev
Beer-Sheva, 84105, Israel
Tel: +972-8-6479611
Fax: +972-8-6472984
E-mail:: [email protected]

Received Date: September 24, 2015; Accepted Date: October 28, 2015; Published Date: October 30, 2015

Citation: Elia P, Raizelman S, Katorza E, Matana Y, Zeiri O, et al.(2015) Biomarkers for the Detection of Pre-Cancerous Stage of Cervical Dysplasia. J Mol Biomark Diagn 6:255. doi:10.4172/2155-9929.1000255

Copyright: © 2015 Elia P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Introduction: Early diagnosis of cancer can dramatically increase healing probability. However many cancer detection methods are time-consuming, invasive, and require skilled medical staff and/or expensive detection systems. Cervical cancer is the fourth most common malignant disease among women, and the fourth leading cause of cancer death in women worldwide.

Aim: This pilot study sought to identify reliable biomarkers indicative of early stages of cervical dysplasia, by analysis of changes in volatile organic compound composition in urine samples.

Methods: Urine samples of 17 patients with cervical intraepithelial neoplasia (CIN I) and of 9 healthy female subjects were used. The sample composition was analyzed using Gas-Chromatography-Mass-Spectrometry. The statistical analysis of the data was performed using supervised artificial neural networks.

Results: We identified four molecules with potential to serve as biomarkers of cervical dysplasia together with two molecules whose absence in the urine can confirm existence of cervical dysplasia. All indications shows that these six potential biomarkers are produced in the body during various physiological processes enhances in sick women. Hence, these potential biomarkers are not related to environmental or dietary origins.

Conclusion: Validation of the statistical method used, indicated that the biomarkers identified are highly reliable for detection of cervical dysplasia.


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