alexa Biomaterials for Promoting Wound Healing in Diabetes
ISSN: 2157-7552

Journal of Tissue Science & Engineering
Open Access

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Biomaterials for Promoting Wound Healing in Diabetes

Juan Liu1,2, Huaiyuan Zheng1,2, Xinyi Dai1, Shicheng Sun3, Hans-Günther Machens1 and Arndt F Schilling1,4*

1Department of Plastic Surgery and Hand Surgery, Klinikum Rechts der Isar, Faculty of Medicine, Technische Universität München, Munich, Germany

2Department of Hand Surgery, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

3Department of Cardiology, Klinikum Rechts der Isar, 1st Medicine Clinic, Technische Universität München, Munich, Germany

4Clinic for Trauma Surgery, Orthopaedic Surgery and Plastic Surgery, University Medical Center Göttingen, Germany

*Corresponding Author:
Arndt F Schilling
Clinic for Trauma Surgery
Orthopaedic Surgery and Plastic Surgery
University Medical Center Göttingen
Göttingen, Germany
Tel: +49 (0)551 39 20401
E-mail: [email protected]

Received date: January 27, 2017; Accepted date: February 21, 2017; Published date: February 27, 2017

Citation: Liu J, Zheng H, Dai X, Sun S, Machens HG, et al. (2017) Biomaterials for Promoting Wound Healing in Diabetes. J Tissue Sci Eng 8:193. doi: 10.4172/2157-7552.1000193

Copyright: © 2017 Liu J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Impaired wound healing is the leading cause of non-traumatic lower limb amputation in people with diabetes mellitus. Skin substitutes engineered from biomaterials currently play an important role in the healing process of diabetic wounds, especially those wounds that fail to show progress after standard wound care. This article summarizes current developments of biomaterials used for promoting the wound healing process in either diabetic animal models or patients with diabetes mellitus. Those biomaterials can be categories into tissue-derived scaffolds, hydrogel-based biomaterials and biomaterials with controlled-release of signaling molecules. Tissue-derived scaffolds maintain perfect extracellular matrix architectures for three-dimensional cell growth and rebuilding of multi-layer tissue structures within scaffolds after implantation. Hydrogel-based biomaterials are engineered to resemble the natural extracellular matrix for cell invasion and capillary growth. Biomaterials processed with cells or controlled-release of signaling molecules (growth factors, cytokines) can induce angiogenesis, re-epithelialization, cell recruitment and migration as well as inhibit consistent inflammation, thereby accelerating the wound healing process. Better understanding of the mechanism of diabetic wound healing will lead to the development of even better biomaterials possibly with inclusion of engineered patient derived cells or factors which will aid in vivo vascularization and consistent release of tissue-inductive signals. By reviewing the recent literature, we draw future perspectives on new strategies for further improvement of the individualized therapy of diabetic wounds.

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