alexa Biomimetic Calcium Phosphate Coatings for Polymeric Art
ISSN:2090-5025

Bioceramics Development and Applications
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Research Article

Biomimetic Calcium Phosphate Coatings for Polymeric Artificial Spinal Disc Implants

D. H. Barnes1*, R. E. Cameron1, S. Kiamil,2 F. Meyer3, R. A. Brooks3, N. Rushton3, and S. M. Best1

1Cambridge Centre for Medical Materials, Department of Materials Science & Metallurgy, University of Cambridge, Cambridge CB2 3QZ, UK

2Ranier Technology Ltd., Cambridge CB5 8AA, UK

3Orthopaedic Research Unit, Addenbrooke’s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK

Corresponding Author:
D. H. Barnes
Cambridge Centre for Medical Materials
Department of Materials Science & Metallurgy
University of Cambridge, Cambridge CB2 3QZ, UK
Email: [email protected]

Received date: 11 November 2010; Accepted date: 02 December 2010

 

Abstract

Discs of poly carbonate urethane (PCU) were coated with a thin layer of calcium phosphate (CaP) by a biomimetic process at temperatures of 28?C and 37?C. The coating morphology was analyzed by SEM. Contact angle analysis was used to assess surface wettability. Human osteoblasts (HOBs) were cultured on uncoated and CaP-coated PCU discs for up to 14 days. Cell metabolism, structure, and morphology were analyzed and compared with the wettability of each sample group. HOBs proliferated and grew on uncoated and CaP-coated samples, but a greater cell metabolism was observed for uncoated samples at early time points in cell culture. A more even dispersion of HOBs across the disc surface, attributable to the increased surface wettability, was seen for CaP-coated samples.

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