alexa Biomimetic Oral Appliance Therapy in Adults with Severe Obstructive Sleep Apnea
ISSN: 2167-0277

Journal of Sleep Disorders & Therapy
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Research Article

Biomimetic Oral Appliance Therapy in Adults with Severe Obstructive Sleep Apnea

G. Dave Singh1*, Tara Griffin2 and Samuel E Cress3
1BioModeling Solutions, Inc., 17933 NE Evergreen Parkway, Beaverton, USA
2Emerald Coast Dental Sleep Medicine, Panama City Beach, FL 32408, USA
3Craniofacial and Dental Sleep Medicine, Sugar Land, TX 77479, USA
Corresponding Author : Prof. G. Dave Singh
BioModeling Solutions
Inc., 17933 NE Evergreen Parkway
Suite 280, Beaverton, OR 97006, USA
Tel: +1 971-302-2233
Received: January 07, 2016; Accepted: January 21, 2016; Published: January 28, 2016
Citation: Singh GD, Griffin T, Cress SE (2016) Biomimetic Oral Appliance Therapy in Adults with Severe Obstructive Sleep Apnea. J Sleep Disord Ther 5:227. doi:10.4172/2167-0277.1000227
Copyright: © 2016 Singh GD, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Introduction: While Continuous Positive Airway Pressure (CPAP) is widely used to manage Obstructive Sleep Apnea (OSA), compliance can be problematic in some cases. These patients are often referred for Mandibular Advancement Devices (MADs) but there is less evidence of their efficacy in severe cases. We investigated the use of biomimetic oral appliance therapy (BOAT) to test the hypothesis that severe cases of OSA can be addressed using BOAT.

Materials and Methods: 15 consecutive adults aged >21 yrs with severe OSA that were unable to comply with CPAP according to a medical physician were treated using BOAT with or without primary mandibular advancement by a dentist with advanced training in dental sleep medicine. The mean Apnea-Hypopnea Index (AHI) of the sample was calculated prior to and after BOAT with no appliance in the mouth during the sleep studies. The findings were subjected to statistical analysis, using paired t-tests.

Results: Prior to treatment the mean AHI of the study sample was 45.9 hr-1 ± 10.5. A follow-up sleep study at 9.7 mos. ± 1.9 showed a 64% decrease in AHI to a mean value of 16.5 hr-1 ± 8.8 after BOAT (p<0.01) with no appliance in the mouth during the post-treatment sleep studies. Results for those without primary mandibular advancement were: 46.6 hr-1 ± 12.9 pre-treatment vs. 13.9 hr-1 ± 10.5 after BOAT (p<0.01); and for those treated with initial mandibular advancement: 45.2 hr-1 ± 8 pre-treatment vs. 19.5 hr-1 ± 6 after BOAT (p<0.01).

Conclusions: BOAT may be a useful method of managing severe cases of OSA in adults, and represents an alternative to CPAP and MADs. However, long-term follow up is needed to reach more definitive conclusions on these initial findings.


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