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ISSN: 2155-6210

Journal of Biosensors & Bioelectronics
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Research Article

Biomolecular Mimic Circuit for an Allosterically Regulated Enzyme of Pyrimidine Biosynthetic Pathway

R.Vinoth1 and S. Balaji2*

1Department of Electronics and Communication, Manipal Institute of Technology, Manipal University, Manipal -576104

2Department of Biotechnology, Manipal Institute of Technology, Manipal University, Manipal -576104

*Corresponding Author:
S. Balaji
Department of Biotechnology
Manipal Institute of Technology, Manipal University
Manipal-576104, Udupi (Dt.), Karnataka, India
Tel: +9109036260732
E-mail: [email protected], [email protected]

Received Date: December 17, 2011; Accepted Date: January 18, 2012; Published Date: January 22, 2012

Citation: Vinoth R, Balaji S (2012) Biomolecular Mimic Circuit for an Allosterically Regulated Enzyme of Pyrimidine Biosynthetic Pathway. J Biosens Bioelectron 3:117 doi: 10.4172/2155-6210.1000117

Copyright: © 2012 Vinoth R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

A general type of molecular level metabolic control that is common to all living organisms is the feedback inhibition, wherein an increase in the product of a metabolic pathway regulates an enzyme upstream in the cascade by binding to it and decreasing enzyme activity. The de novo pyrimidine biosynthetic pathway provides a specific example for the feedback inhibition. Aspartate transcarbamoylase (ATCase) catalyzes the first step in the biosynthesis of pyrimidines and one of the best understood allosteric enzymes. The structure of ATCase is roughly triangular in shape, similar to the symbol of an op-amp IC. Since most of the enzymatic properties were analogous to the properties of IC, this inspired us to mimic the enzyme (EC 2.1.3.2) with an IC (PIN μ A741CN) in our circuit design. The Michaelis-Menten model, Lineweaver-Burk equation and the equation for the non-inverting amplifier were theoretically related and used for our model. As a result, an electronic feedback circuit was designed and tested. The biomolecular mimic circuit will develop a new level of understanding of the metabolic complexity in the cell.

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