alexa Biophysical EPR Studies Applied to Membrane Proteins | OMICS International| Abstract

ISSN: 2161-0398

Journal of Physical Chemistry & Biophysics

  • Review Article   
  • J Phys Chem Biophys 2015, Vol 5(6): 188
  • DOI: 10.4172/2161-0398.1000188

Biophysical EPR Studies Applied to Membrane Proteins

Indra D Sahu and Gary A Lorigan*
Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, United States of America
*Corresponding Author : Gary A Lorigan, Department of Chemistry and Biochemistry, Miami University, Oxford, OH 45056, USA, Tel: (513) 529-2813, Fax: (513) 529-5715, Email: [email protected]

Received Date: Sep 16, 2015 / Accepted Date: Nov 05, 2015 / Published Date: Nov 10, 2015

Abstract

Membrane proteins are very important in controlling bioenergetics, functional activity, and initializing signal pathways in a wide variety of complicated biological systems. They also represent approximately 50% of the potential drug targets. EPR spectroscopy is a very popular and powerful biophysical tool that is used to study the structural and dynamic properties of membrane proteins. In this article, a basic overview of the most commonly used EPR techniques and examples of recent applications to answer pertinent structural and dynamic related questions on membrane protein systems will be presented.

Keywords: Membrane proteins; Electron paramagnetic resonance spectroscopy; Site-directed spin labeling; DEER; Structural topology and dynamics

Citation: Sahu ID, Lorigan GA (2015) Biophysical EPR Studies Applied to Membrane Proteins. J Phys Chem Biophys 5: 188. Doi: 10.4172/2161-0398.1000188

Copyright: © 2015 Sahu ID, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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  1. aram
    Posted on Jan 02 2017 at 7:46 pm
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