Biopsy Findings in Renal Allograft Dysfunction in a Live Related Renal Transplant Program
Javed I Kazi and Muhammed Mubarak*
Department of Histopathology, Sindh Institute of Urology and Transplantation, Karachi
- *Corresponding Author:
- Dr. Muhammed Mubarak
Department of Histopathology
Sindh Institute of Urology and Transplantation
Tel: 009221 99215752
Fax: 009221 32726165
E-mail: [email protected]
Received Date: September 26, 2011; Accepted Date: October 31, 2011; Published Date: November 03, 2011
Citation: Kazi JI, Mubarak M (2012) Biopsy Findings in Renal Allograft Dysfunction in a Live Related Renal Transplant Program. J Transplant Technol Res 2: 108. doi: 10.4172/2161-0991.1000108
Copyright: © 2012 Kazi JI, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: There is little information in literature on renal allograft biopsy findings in renal allograft dysfunction in live related renal transplant recipients.
Material and Methods: A retrospective review of 1210 renal allograft biopsies from 575 renal transplant patients was carried out over a period of seven years from June 1997 till December 2004. The demographic, clinical, laboratory and biopsy findings were collected and analyzed.
Results: A total of 1210 graft biopsies were performed on 575 patients. The mean age of recipients and donors was 29.2±9.7 years, and 35.7±10.5 years, respectively. The males were predominant among recipients (76.7 vs. 23.3%), while among donors they only slightly outnumbered females (51.8 vs. 48.2%).
Regarding pathological lesions, acute rejection was seen in 292 (24%) cases, followed by acute tubular injury and cyclosporine A (CsA) toxicity, found in 281 (23.2%) and 134 (11%) cases respectively. Chronic allograft nephropathy (CAN) with variable degree of tubular atrophy was seen in 361 (29.8%) cases. Seventy nine cases (6.5%) of acute pyelonephritis were detected on graft biopsies. A number of rare lesions were also found, including 13 (1.07%) cases of recurrent/de novo renal disease, and 13 (1.07%) of polyoma virus infection. Five cases of CsA induced hemolytic uremic syndrome (HUS) were also noted.
Conclusion: In conclusion, the incidence of acute rejection is low in our patients as compared to cadaveric renal transplant recipients as reported in Western studies and CsA toxicity is more common. Recurrent/de novo renal disease is uncommon in our patients.