alexa Biotransformation of Hydrazine Dervatives in the Mechan
ISSN: 2157-7609

Journal of Drug Metabolism & Toxicology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Biotransformation of Hydrazine Dervatives in the Mechanism of Toxicity

Birandra K Sinha* and Ronald P Mason

Laboratory of Pharmacology and Toxicology, National Institutes of Environmental Health Sciences, NIH, USA

*Corresponding Author:
Birandra K Sinha
Laboratory of Pharmacology and Toxicology
National Institutes of Environmental Health Sciences
NIH, Research Triangle Park, North Carolina, N.C 27709, USA
E-mail: [email protected]

Received Date: June 17, 2014; Accepted Date: July 01, 2014; Published Date: July 08, 2014

Citation: Sinha BK, Mason RP (2014) Biotransformation of Hk/ydrazine Dervatives in the Mechanism of Toxicity. J Drug Metab Toxicol 5:168. doi: 10.4172/2157-7609.1000168

Copyright: © 2014 Sinha BK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Hydrazine derivatives are environmental and food pollutants but are also important because of their use in medicine for the treatment of tuberculosis and cancer. However, hydrazines also pose significant health risks to humans as they are mutagenic and carcinogenic. This review examines various metabolic pathways (enzymatic and non-enzymatic) of hydrazines for the formation of reactive species that bind to cellular macromolecules and lead to cellular dysfunction. It is believed that this biotransformation is responsible for the pharmacology and pathophysiology of hydrazine derivatives.


Share This Page

Additional Info

Loading Please wait..
Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version