Biotransformation of Hydrazine Dervatives in the Mechanism of ToxicityBirandra K Sinha* and Ronald P Mason
Laboratory of Pharmacology and Toxicology, National Institutes of Environmental Health Sciences, NIH, USA
- *Corresponding Author:
- Birandra K Sinha
Laboratory of Pharmacology and Toxicology
National Institutes of Environmental Health Sciences
NIH, Research Triangle Park, North Carolina, N.C 27709, USA
E-mail: [email protected]
Received Date: June 17, 2014; Accepted Date: July 01, 2014; Published Date: July 08, 2014
Citation: Sinha BK, Mason RP (2014) Biotransformation of Hk/ydrazine Dervatives in the Mechanism of Toxicity. J Drug Metab Toxicol 5:168. doi: 10.4172/2157-7609.1000168
Copyright: © 2014 Sinha BK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Hydrazine derivatives are environmental and food pollutants but are also important because of their use in medicine for the treatment of tuberculosis and cancer. However, hydrazines also pose significant health risks to humans as they are mutagenic and carcinogenic. This review examines various metabolic pathways (enzymatic and non-enzymatic) of hydrazines for the formation of reactive species that bind to cellular macromolecules and lead to cellular dysfunction. It is believed that this biotransformation is responsible for the pharmacology and pathophysiology of hydrazine derivatives.