alexa BK Polyomavirus in Renal Transplantation
ISSN: 2327-5146

General Medicine: Open Access
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Review Article

BK Polyomavirus in Renal Transplantation

Alice Kennard1, Prof David W Johnson1,2,3 and Ross Francis1,2,3*
1Department of Nephrology, Princess Alexandra Hospital, Brisbane, Australia
2School of Medicine, University of Queensland, Brisbane, Australia
3Translational Research Institute, Brisbane, Australia
Corresponding Author : Dr Ross Francis
Department of Nephrology, Level 2
ARTS Building, Princess Alexandra Hospital
Ipswich Road, Woolloongabba, Brisbane Qld 4102, Australia
Tel: +61 7 3176 5080
Fax: +61 7 3176 5480
E-mail: [email protected]
Received September 10, 2014; Accepted November 13, 2014; Published December 02, 2014
Citation: Kennard A, Johnson DW, Francis R (2015) BK Polyomavirus in Renal Transplantation. Gen Med (Los Angel) 3:154 doi: 10.4172/2327-5146.1000154
Copyright: ©2015 Kennard A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

BK virus is a human polyomavirus that rarely causes disease, except in immune-compromised patients. Evidence of prior BK Virus (BKV) infection is highly prevalent in the general population, and although it rarely causes significant morbidity at primary infection, reactivation of BKV after kidney transplantation is recognized as a cause of BKV-associated Nephropathy (BKVAN), ureteric stenosis, and, rarely, haemorrhagic cystitis. The incidence of BKVAN appears to be increasing, most likely because of increased surveillance post-transplant, as well as the use of more potent immunosuppressive agents. Many patients with BKVAN experience progressive kidney dysfunction and the disease represents a significant threat to long-term kidney transplant success. This narrative review will discuss the epidemiology, risk factors, clinical features, screening, diagnosis and management of BKV infection in the setting of kidney transplantation, as well as suggest future research directions.

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