alexa Black Tea Polyphenols Suppress Postprandial Hyperglycemia In Vivo in Mice and Inhibit α-Glucosidase Activity In Vitro
ISSN: 2167-0943

Journal of Metabolic Syndrome
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Research Article

Black Tea Polyphenols Suppress Postprandial Hyperglycemia In Vivo in Mice and Inhibit α-Glucosidase Activity In Vitro

Junki Yoshida#, Akiko Tateishi#, Yuko Fukui*, Mitsuhiro Zeida and Nobuyuki Fukui
Research Division, Suntory Global Innovation Center Limited (Suntory SIC), Seikadai, Seika-cho, Soraku-gun, Kyoto 619-0284, Japan
#Both the authors Contributed equally to the work.
*Corresponding Author : Yuko Fukui
Ph.D., Research Division
Suntory Global Innovation Center Limited (Suntory SIC)
8-1-1 Seikadai, Seika-cho, Soraku-gun
Kyoto 619-0284, Japan
Tel: +81-50-3182-0456
Fax: +81-774-98-6262
E-mail: [email protected]
Received: November 28, 2015; Accepted: December 22, 2015; Published: December 29, 2015
Citation: Yoshida J, Tateishi A, Fukui Y, Zeida M, Fukui N (2015) Black Tea Polyphenols Suppress Postprandial Hyperglycemia In Vivo in Mice and Inhibit α-Glucosidase Activity In Vitro. J Metabolic Synd 5:194. doi:10.4172/2167- 0943.1000194
Copyright: © 2015 Yoshida J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Black tea is reported to have various beneficial effects on health. Activated charcoal-treated black tea (ACBT) did not contain catechins nor caffeine and included small amount of theaflavins (TFs). We had further fractionated ACBT to obtain black tea polymerized polyphenols (BTPP), TFs-poor fraction and TFs-rich fraction and studied in vitro and/or in vivo effect of the fractions to elucidate the effect of ACBT. Sucrose-loading test in mice showed that ACBT and BTPP at the dose of, 1000 and 560 mg/kg, respectively, suppressed the increase of blood glucose level while secretion of insulin was not affected. We found that this effect is caused by inhibition of α-glucosidase activity. BTPP contained TFs, but the content was not at all enough to explain the activity of ACBT, 1H NMR analysis of BTPP was carried and showed the existence of many benzotropolone ring containing substances as active compounds.

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