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Blastic Plasmacytoid Dendritic Cell Neoplasm: Report Of A Case | OMICS International | Abstract
ISSN: 2155-9554

Journal of Clinical & Experimental Dermatology Research
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Case Report

Blastic Plasmacytoid Dendritic Cell Neoplasm: Report Of A Case

Massimiliano Scalvenzi1*, Lucia Gallo1, Franco Palmisano1, Massimo Mascolo2, Orlando Zagaria1 and Gaetano De Rosa2

1Departments of Dermatology, Federico II University, Naples, Italy

2Biomorphological and Functional Sciences, Federico II University, Naples, Italy

*Corresponding Author:
Massimiliano Scalvenzi
via Pansini 5, Naples, 80131, Italy
Fax: 0817462442
E-mail: [email protected]

Received Date: October 03, 2012; Accepted Date:October 13, 2012; Published Date: October 22, 2012

Citation: Scalvenzi M, Gallo L, Palmisano F, Mascolo M, Zagaria O, et al. (2012) Blastic Plasmacytoid Dendritic Cell Neoplasm: Report of a Case. J Clin Exp Dermatol Res S6:001. doi: 10.4172/2155-9554.S6-001

Copyright: © 2012 Scalvenzi M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Blastic plasmacytoid dendritic cell neoplasm (BPDCN), also known as CD4+/CD56+ hematodermic neoplasm, is a rare, highly aggressive hematopoietic malignancy characterized by cutaneous, lymph node and bone marrow involvement, high risk of a leukemic dissemination, and a poor prognosis. It has been recognized as an independent entity in the World Health Organization (WHO) 2008 classification for cutaneous lymphomas and is thought to be derived from the precursors of plasmacytoid dendritic cells. This neoplasm most commonly affects middle-aged or elderly patients with predominant skin or soft tissue involvement. We report a case of a 87-year-old man with a purplered plaque on his face and multiple purple-red nodules on his trunk. Histopathology and immunohistological staining confirmed the diagnosis of blastic plasmacytoid dendritic cell neoplasm.

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