alexa Bleeding Kinetics after Total Hip or Knee Replacement: A Prospective Observational Study
ISSN: 2155-6148

Journal of Anesthesia & Clinical Research
Open Access

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Research Article

Bleeding Kinetics after Total Hip or Knee Replacement: A Prospective Observational Study

Thomas Giral1*, Antoine Tesniere1 , Lorenn Bellamy1 , Yves Ozier2 , Charles Marc Samama1 and Nadia Rosencher1

1Department of Anesthesia and Intensive Care, Cochin University Hospital, Assistance Publique, Hopitaux de Paris, University Paris Descartes, Paris, France

2Division of Anesthesia, Intensive Care and Emergency Medicine, Brest University Hospital, Brest, France

*Corresponding Author:
Thomas Giral
Department of Anesthesia and Intensive Care
Cochin University Hospital, Assistance Publique
Hopitaux de Paris, University Paris Descartes, Paris, France
Tel: +33 6 86 32 66 23
E-mail: [email protected]

Received Date: September 14, 2013; Accepted Date: September 28, 2013; Published Date: September 30, 2013

Citation: Giral T, Tesniere A, Bellamy L, Ozier Y, Samama CM, et al. (2013) Bleeding Kinetics after Total Hip or Knee Replacement: A Prospective Observational Study. J Anesth Clin Res 4:355.doi: 10.4172/2155-6148.1000355

Copyright: © 2013 Giral T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background and objectives: The objective was to assess the kinetics of postoperative bleeding after total hip or knee replacement, with or without administration of tranexamic acid, in order to anticipate red blood cell transfusion thresholds in the recovery room.

Materials and methods: This was a prospective, observational, single-center study. All patients undergoing primary or revision total hip or knee replacement were enrolled for two months. Patients were managed using a multimodal strategy designed to reduce the need for red blood cell transfusion. Postoperative bleeding kinetics was assessed according to the drop of hemoglobin levels between the arrival in the recovery room and day one after surgery.

Results: A total of 106 patients were included. The mean transfusion rate was 18%. Nadir hemoglobin levels were observed on day + 2, and about 60% of bleeding occurred during the postoperative period, with a drop of 1.2 ± 0.2 g/dL between the recovery room and day one for patients receiving tranexamic acid, and 1.9 ± 0.2 g/dL for those not receiving tranexamic acid (p=0.018).

Discussion: In our center, the hemoglobin transfusion threshold in recovery room might be raised by 1 or 2 g/ dL depending on whether tranexamic acid is used.

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