alexa Blood B Cell and Regulatory Subset Content in Multiple
ISSN: 2376-0389

Journal of Multiple Sclerosis
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Research Article

Blood B Cell and Regulatory Subset Content in Multiple Sclerosis Patients

Jakob Habib1, Jiusheng Deng1, Neil Lava2, William Tyor2,3 and Jacques Galipeau1*

1Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, 1365 Clifton Rd NE, Atlanta, Georgia 30322, USA

2Department of Neurology, Emory MS Center, 1365 Clifton Rd NE, Atlanta, Georgia, 30322, USA

3Department of Neurology (GEC), Atlanta VA Medical Center, 1670 Clairmont Road, Decatur, GA 30033

*Corresponding Author:
Jacques Galipeau
Department of Hematology and Medical Oncology
Pediatrics & Medicine, School of Medicine
Emory University, Atlanta, Georgi, USA
Tel: 404-778-1779
E-mail: [email protected]

Received date: March 24, 2015; Accepted date: April 25, 2015; Published date: May 04, 2015

Citation: Habib J, Deng J, Lava N, Tyor W, Galipeau J (2015) Blood B Cell and Regulatory Subset Content in Multiple Sclerosis Patients. J Mult Scler 2:139. doi:10.4172/2376-0389.1000139

Copyright: © 2015 Habib J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Objective:

B cell targeted therapies have been effective in slowing multiple sclerosis (MS) disease progression suggesting a direct causal link for this lymphoid subset. A small subset of B cells with regulative properties (Bregs) exists in peripheral blood, and induction of Bregs ameliorates experimental autoimmune encephalomyelitis (EAE), the murine model for MS. Therefore the frequency of B cell subsets and regulatory B cells in particular in peripheral blood of MS patients is of interest.

Methods: The phenotype and frequency of B cell subsets in peripheral blood from 32 MS patients and 34 healthy controls (HC) were examined using flow cytometry. Results: We found that there is an increase in CD19+ cell number in MS 1347 ± 159 cells/μL, (average ± SEM) compared to HC, 935 ± 129 cells/μL and no apparent deficiency in B-cells with a regulatory phenotype. In addition, we observed a loss of correlation between CD19+ B cells and total lymphocyte count in MS.

Conclusion: These findings suggest altered blood B-cell homeostasis in MS patients.

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