alexa Blood Biological Markers for Prediction of Escitalopram Response in Patients with Major Depressive Disorder: Preliminary Study
ISSN: 2167-1044

Journal of Depression and Anxiety
Open Access

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Research Article

Blood Biological Markers for Prediction of Escitalopram Response in Patients with Major Depressive Disorder: Preliminary Study

Masato Yamana, Kiyokazu Atake, Asuka Katsuki, Hikaru Hori and Reiji Yoshimura*
Department of Psychiatry, University of Occupational and Environmental Health, Japan
*Corresponding Author : Reiji Yoshimura
Department of Psychiatry, University of Occupational and Environmental Health
1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka8078555, Japan
Tel: +81936917253
Fax: +81936924894
E-mail: [email protected]
Received: February 10, 2016; Accepted: February 29, 2016; Published: March 03, 2016
Citation: Yamana M, Atake K, Katsuki A, Hori H, Yoshimura R (2016) Blood Biological Markers for Prediction of Escitalopram Response in Patients with Major Depressive Disorder: Preliminary Study. J Depress Anxiety 5:222. doi:10.4200/2167-1044.1000222
Copyright: © 2016 Yamana M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Introduction: Lots of studies have been performed to predict the response to antidepressants in patients with major depressive disorder. The findings were however controversial. Objective: The aim of the present study was to investigate the relationship between response to escitalopram and several peripheral biomarkers in major depressive disorder (MDD).

Material and Methods: Forty-eight MDD patients diagnosed by DSM-IV-TR were enrolled the study, and all were treated with escitalopram. The end-point of the study was 8 weeks after starting the treatment. Twenty-seven patients were completed the study. Their depressive symptoms were evaluated using the 17-items Hamilton Rating Scale for Depression (HAMD17). The patients whose HAMD17 reduced 50% or more at 8 weeks were defined as responders. The peripheral biomarkers were assayed with ELISA or high-performance liquid chromatography.

Results: Plasma 3-methoxy-4-hydroxyphenil glycol (MHPG) level at starting escitalopram in the responders were significantly higher than those in nonresponders (p = 0.0032). Any other factors were not different between the responders and the nonresponders.

Conclusion: These results suggest that MHPG level can predict the response to escitalopram

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