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Blood Coagulation Thromboplastine Time Measurements on a Nanoparticle Coated Quartz Crystal Microbalance Biosensor in Excellent Agreement with Standard Clinical Methods | Abstract
ISSN: 2155-6210

Journal of Biosensors & Bioelectronics
Open Access

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Research Article

Blood Coagulation Thromboplastine Time Measurements on a Nanoparticle Coated Quartz Crystal Microbalance Biosensor in Excellent Agreement with Standard Clinical Methods

Munawar Hussain1, Stefan Sinn1, Martin Zeilinger2, Hinnak Northoff1, Peter A Lieberzeit2 and Frank K Gehring1*

1Biosensor Research Group, Institute of Clinical and Experimental Transfusion Medicine, Tuebingen University, Germany

2University of Vienna, Department of Analytical Chemistry, Währinger Strasse, Vienna, Austria

*Corresponding Author:
Frank K Gehring
Biosensor Research Group
Institute of Clinical and Experimental Transfusion Medicine
Tuebingen University, Germany
E-mail: [email protected]

Received Date: July 31, 2013; Accepted Date: August 21, 2013; Published Date: August 30, 2013

Citation: Hussain M, Sinn S, Zeilinger M, Northoff H, Lieberzeit PA, et al. (2013) Blood Coagulation Thromboplastine Time Measurements on a Nanoparticle Coated Quartz Crystal Microbalance Biosensor in Excellent Agreement with Standard Clinical Methods. J Biosens Bioelectron 4:139. doi: 10.4172/2155-6210.1000139

Copyright: © 2013 Hussain M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Measurements of parameters of hemostasis like thromboplastine time (PT) have primary significance in many clinical settings including extensive surgery, dialysis or innate disorders of hemostasis. Recently, several reports have documented the principle suitability of Quartz Crystal Microbalances (QCM) for measuring parameters of hemostasis like PT or platelet aggregation. But for the establishment of an exact QCM based method as alternative to standard coagulometer measuring QCM coatings with significantly enhanced robustness and reusability have to be worked out. For this purpose we utilized a new semi-automated equipment qCell T for measuring and compared different coatings consisting of polymer films and absorbed nanoparticles (NPs). We demonstrated that affinity based poly ethylene NPs absorbed to polymer films on the QCM constitute a powerful tool with no need for pretreatment for measuring PT in whole blood samples in real time, while these coatings are reusable up to 10 times. PT measurements in excellent agreement with coagulometer tests pave the way for possible future application of QCM in clinical routine.

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