Blood Glutathione Peroxidase Activity in Relation with the Risk of Cardiovascular Diseases in Obese WomenMarie-Eve Lavoie1,2, Rémi Rabasa-Lhoret1,2,3, Sophie Ziai1,2 and Jean-Claude Lavoie1,4*
- Corresponding Author:
- Jean-Claude Lavoie
Department of Nutrition, Université de Montréal
Research Center, CHU Sainte-Justine
3175 Côte Ste-Catherine, Montreal, QC, Canada, H3T 1C5
Tel: (514) 345-4931 #3940
Fax: (514) 345-4801
E-mail: [email protected]
Received Date: July 25, 2011; Accepted Date: August 18, 2011; Published Date: September 08, 2011
Citation: Lavoie M, Rabasa-Lhoret R, Ziai S, Lavoie J (2011) Blood Glutathione Peroxidase Activity in Relation with the Risk of Cardiovascular Diseases in Obese Women. J Diabetes Metab 2:136. doi:10.4172/2155-6156.1000136
Copyright: © 2011 Lavoie M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: Oxidative stress plays a role in obesity-related diseases. We hypothesize that abnormalities of the glutathione system are associated with the initial phase leading to development of cardiometabolic abnormalities such as cardiovascular diseases and type 2 diabetes in apparently healthy obese women. By measuring different glutathione parameters, we expect to find a dichotomy that can discriminate between obese women who have such sub-clinical abnormalities. Subjects: This is a cross-sectional analysis in 59 postmenopausal obese women. Total blood glutathione, glutathione peroxidase (GPx) and glutathione reductase activity, blood lipids, apolipoprotein B-100 (apoB), fasting and area under the curve (AUC) for glycemia and insulinemia during an oral glucose tolerance test, insulin sensitivity measurement and indices, serum inflammatory markers and carotid intima-media thickness (CIMT, by magnetic resonance imaging) were measured. Results: Blood GPx activity had a bimodal distribution. Subjects were then divided into two groups according to their GPx activity (cut-off: 2.0 nmol/min/mg protein, P<0.01). Age and BMI were similar between the groups. Women with higher GPx activity had 13% more apoB (P=0.02), 10% higher glycemia AUC (P=0.04), hepatic insulin resistance (28% and 25% higher HOMA and liver insulin resistance index values, P<0.04) and increased CIMT by 8-13% (P=0.013) without evidence of inflammation, changes in blood lipids, and fasting glycemia and insulinemia. Conclusion: Results suggest that a modification in the glutathione system is associated with insulin resistance and increased intima-media thickness, both of which are associated with cardiovascular disease risk. Blood GPx activity may be a parameter contributing in the identification of sub-clinical but clinically relevant asymptomatic cardiometabolic abnormalities in obese women.