alexa Bloodless Liver Transplantation: ROTEM guided Rational
ISSN: 2155-6148

Journal of Anesthesia & Clinical Research
Open Access

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Research Article

Bloodless Liver Transplantation: ROTEM guided Rational Prophylactic use of Recombinant Activated Factor VII

Fayed N1*, Hegazy O2 and Tanaka K3

1Department of Anesthesia, Hepatobiliary Surgery, National Liver Institute, Menofeya University, Egypt

2Hepatobiliary Surgery, National Liver Institute, Menofeya University, Egypt

3Hepatobiliary Surgery, Kyoto, Japan

*Corresponding Author:
Nirmeen A Fayed
Department of anesthesia, National Liver Institute
Menofeya University, Egypt
Tel: 00201113320976, 0020482220205
E-mail: [email protected]

Received date: September 04, 2012; Accepted date: September 14, 2012; Published date: September 24, 2012

Citation: Fayed N, Hegazy O, Tanaka K (2012) Bloodless Liver Transplantation: ROTEM guided Rational Prophylactic use of Recombinant Activated Factor VII. J Anesth Clin Res 3:240. doi: 10.4172/2155-6148.1000240

Copyright: © 2012 Fayed N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: Improvement of surgical and anesthetic techniques, allowed total avoidance of blood transfusion during liver transplantation (LT) in some cases. The last years showed much debate about prophylactic administration of rFVIIa with no guide for its rational use. Giving that it is off label, preoperative ROTEM assessed coagulation reserve may help its judicious use. Patients and methods: 3 groups retrospectively studied; (NRNB) n=38 not given rFVIIa and no blood transfusion (BT), (RNB) n=43 given rFVIIa and no BT and (RAB) n=35 given rFVIIa and BT. 40 ug/kg rFVIIa were given. Comparison NRNB vs. RNB group answers need or not need rFVIIa to achieve bloodless surgery (decision of admission), while RNB vs. RAB group determine which patients rFVIIa can help to achieve bloodless surgery ( responders and non responders). Data collected: Preoperative Extem, Fibtem, hemoglobin (HB), INR, platelet, fibrinogen, blood loss, and blood transfused in RAB group.

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