alexa Bloodstream Infection: The Influence of Risk Factors, Etiology and Antimicrobial Therapy on Mortality Rates
ISSN: 2167-1168

Journal of Nursing & Care
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Research Article

Bloodstream Infection: The Influence of Risk Factors, Etiology and Antimicrobial Therapy on Mortality Rates

Rosana de Oliveira Santos Guimarães1, Thúlio Marquez Cunha2, Ana Carolina Souza Oliveira3, Lúcio Borges de Araújo4, Reginaldo dos Santos Pedroso5and Denise Von Dolinger de Brito Röder6

1Program of Post-Graduation in Health Sciences, Federal University of Uberlandia, Uberlandia, Minas Gerais, Brazil

2Faculty of Medicine, Federal University of Uberlandia, Uberlandia, Minas Gerais, Brazil

3Intensive Therapy Unit, Clinical Hospital of the Federal University of Uberlândia, Uberlandia, Minas Gerais, Brazil

4Faculty of Mathematics, Federal University of Uberlandia, Uberlandia, Minas Gerais, Brazil

5School of Health Technician, Federal University of Uberlandia, Uberlandia, Minas Gerais, Brazil

6Institute of Biomedical Sciences, Federal University of Uberlandia, Uberlandia, Minas Gerais, Brazil

*Corresponding Author:
Dra Denise Von Dolinger by Brito Röder
Institute of Biomedical Sciences/Federal University of Uberlândia
Avenida Pará 1720, Campus Umuarama, 38400-320 Uberlândia
Minas Gerais, Brazil
Tel: 55 34 3291-8891
E-mail: [email protected]

Received date: March 04, 2017; Accepted date: April 13, 2017; Published date: April 21, 2017

Citation: Guimarães ROS, Cunha TM, Oliveira ACS, de Araujo LB, Pedroso RS, et al. (2017) Bloodstream Infection: The Influence of Risk Factors, Etiology and Antimicrobial Therapy on Mortality Rates. J Nurs Care 6:391. doi:10.4172/2167-1168.1000391

Copyright: © 2017 Guimarães ROS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

 

Abstract

Introduction: Inappropriate initial antimicrobial therapy leads to higher mortality in patients with bloodstream infection. This study aimed to evaluate the relationship between risk factors, etiology and antimicrobial therapy on mortality rates of patients with bloodstream infection. Methods: Between January 2016 to December 2016, 167 patients with bloodstream infection were prospectively evaluated according to the presence or absence of inappropriate antimicrobial therapy of infection. Hospital mortality was the main outcome variable compared between the two study groups. Results: Infected patients who received inappropriate antimicrobial therapy had statistically more diabetes mellitus, chronic obstructive pulmonary disease, chronic renal disease and death than infected patients who initially received appropriate antimicrobial therapy. Loading dose error and error in starting antimicrobial administration were the most frequently detected error in our study and both were determinant factors related to increased mortality. Initial antimicrobial therapy was maintained, escalation and de-escalation 67.6%, 22.7% and 9.6% of cases, respectively. Coagulase negative staphylococci represented the majority reaching 40.7% and multi-drug resistant microorganisms were detected in 27.3% of infections. There was no observed difference in mortality rates among infections caused by resistant or susceptible microorganisms. Conclusion: Loading dose error and error in starting antimicrobial administration, were the most frequently detected error in our study and both were determinant factors related to increased mortality. Beside the multiple logistic regression analysis revealed that the delay in starting antimicrobial therapy was the only independent factor that increased mortality.

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