alexa Bone Analysis of T-Cell Leukaemia Translocation-Associated Gene (TCTA) Transgenic Mice and Conditional Knockout Mice: Possibility that TCTA Protein Expressed on Osteoclasts Plays a Role as a Novel Coupling Factor In Vivo
ISSN: 2329-9509

Journal of Osteoporosis and Physical Activity
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Research Article

Bone Analysis of T-Cell Leukaemia Translocation-Associated Gene (TCTA) Transgenic Mice and Conditional Knockout Mice: Possibility that TCTA Protein Expressed on Osteoclasts Plays a Role as a Novel Coupling Factor In Vivo

Shigeru Kotake*, Yuki Nanke, Toru Yago, Manabu Kawamoto, Tsuyoshi Kobashigawa and Hisashi Yamanaka

Institute of Rheumatology, Tokyo Women's Medical University, Shinjuku, Tokyo, Japan

*Corresponding Author:
Shigeru Kotake
Institute of Rheumatology, Tokyo Women's Medical University
10-22 Kawada, Shinjuku, Tokyo 162-0054, Japan
Tel: 81-3-5269-1725
Fax: 81-3-5269-1726
E-mail: [email protected]

Received date: March 16, 2017; Accepted date: March 23, 2017; Published date: March 29, 2017

Citation: Kotake S, Nanke Y, Yago T, Kawamoto M, Kobashigawa T, et al. (2017) Bone Analysis of T-Cell Leukaemia Translocation-Associated Gene (TCTA) Transgenic Mice and Conditional Knockout Mice: Possibility that TCTA Protein Expressed on Osteoclasts Plays a Role as a Novel ʻCoupling Factorʼ In Vivo. J Osteopor Phys Act 5:194. doi:10.4172/2329-9509.1000194

Copyright: © 2017 Kotake S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

T-cell leukemia translocation-associated gene (TCTA) protein is expressed ubiquitously in normal human tissues. However, its function has not been clarified. In 2009, we demonstrated that TCTA protein play an important role in human osteoclastogenesis and pit formation of mature human osteoclasts inducing the fusion process of osteoclastogenesis in vitro. In the current study, to clarify the role of TCTA protein in vivo, we generated TCTA gene transgenic, both systemic and osteoclast-specific, mice and osteoclast-specific conditional knockout mice and then analyzed their bones. Surprisingly, in the conditional knockout mice, bone volume decreased despite inhibited osteoclastogenesis. According to these findings, we speculated that TCTA protein expressed on osteoclasts plays a role as a ʻcoupling factorʼ in vivo.

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