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ISSN 2155-6113

Journal of AIDS & Clinical Research
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Research Article

Bone Health in HIV-Infected Children, Adolescents and Young Adults: A Systematic Review

Stephen M Arpadi1,2,3*, Stephanie Shiau1,2, Charlotte Marx-Arpadi1 and Michael T Yin4

1Gertrude H. Sergievsky Center, Columbia University Medical Center, New York, NY, USA

2Department of Epidemiology, Mailman School of Public Health, Columbia University Medical Center, New York, NY, USA

3Department of Pediatrics, Columbia University Medical Center, New York, NY, USA

4Department of Medicine, Division of Infectious Disease, Columbia University Medical Center, New York, NY, USA

*Corresponding Author:
Stephen M. Arpadi, MD, MS
Gertrude H. Sergievsky Center, Columbia University
630 W. 168th Street, PH 19-114
New York, NY 10032, USA
Tel: 2123052384
Fax: 2123052526
E-mail: [email protected]

Received date: August 22, 2014; Accepted date: October 30, 2014; Published date: November 09, 2014

Citation: Arpadi SM, Shiau S, Arpadi CM, Yin MT (2014) Bone Health in HIV-Infected Children, Adolescents and Young Adults: A Systematic Review. J AIDS Clin Res 5: 374. doi:10.4172/2155-6113.1000374

Copyright: © 2014 Arpadi SM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: Children and adolescent, who acquire HIV infection early in life either perinatally, from contaminated blood products or via sexual transmission, have the greatest cumulative exposure to the negative direct and indirect effects of HIV infection and ART on bone. This may lead to increased lifetime risk for osteoporosis and fracture. We conducted a systematic review to evaluate the literature on bone health in children and adolescents with HIV. Methods: We performed a comprehensive search of the Medline, Scopus, and Cochrane Library databases (up to April 1, 2014) for studies that reported on bone imaging or bone fractures in HIV-infected children, adolescents, or young adults. Results: A total of 32 publications met our inclusion criteria. Seventeen studies were cross-sectional and 15 were longitudinal. The majority of studies were conducted in high-income countries, three in middle-income countries and none in low-income countries. Overall, the studies we reviewed indicate that measures of bone mass are reduced, with increased prevalence of low BMD in children and adolescents with HIV. However, the studies are highly variable with respect to comparison sources, measurement methods, adjustment techniques for body size or growth retardation, and highlighted risk factors, including aspects related to medication exposures as well as the effects of HIV infection per se. Conclusions: HIV infection appears to be associated with decreased bone accrual throughout childhood and adolescence. Sub-optimal bone accrual may persist through childhood and adolescence and result in reduced peak bone mass, an important determinant of future risk of osteoporosis and fracture. Important areas for future research include evaluation of bone mass, bone quality and fracture risk across the life course among those with early-life infection with HIV, particularly in resource-limited settings where the majority of children with HIV live.


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