alexa Bone Marrow Necrosis and Elevated Plasma Levels of Fas Ligand in a Patient with Aggressive Natural Killer Cell Leukemia
ISSN: 2327-5146

General Medicine: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Case Report

Bone Marrow Necrosis and Elevated Plasma Levels of Fas Ligand in a Patient with Aggressive Natural Killer Cell Leukemia

Yoshiko (Fujimoto) Hirakawa1*, Kyoko (Taniguchi) Yoshihara2, Hiroto Kaneko3, Hitoji Uchiyama1, Junya Kuroda4 and Masafumi Taniwaki4

1Department of Hematology, Japanese Red Cross Kyoto Daiichi Hospital, Honmachi, Higashiyama-ku, Kyoto, Japan

2Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho, Nishinomiya City, Hyogo, Japan

3Department of Hematology, Aiseikai Yamashina Hospital, Takehana-Shichono-cho, Yamashina-ku, Kyoto, Japan

4Department of Hematology and Oncology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan

*Corresponding Author:
Yoshiko (Fujimoto) Hirakawa
Department of Hematology
Japanese Red Cross Kyoto Daiichi Hospital
15-749 Honmachi, Higashiyama-ku
Kyoto 605-0981, Japan
Tel: +81-75-561-1121
Fax: +81-75-561-6308
E-mail: [email protected]

Received date: June 28, 2016; Accepted date: July 25, 2016; Published date: July 31, 2016

Citation: Yoshiko (Fujimoto) Hirakawa, Kyoko (Taniguchi) Yoshihara, Hiroto Kaneko, Hitoji Uchiyama, Junya Kurodam, et al. (2016) Bone Marrow Necrosis and Elevated Plasma Levels of Fas Ligand in a Patient with Aggressive Natural Killer Cell Leukemia. Gen Med (Los Angeles) 4:263. doi:10.4172/2327-5146.1000263

Copyright: © 2016 Yoshiko (Fujimoto) Hirakawa, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Fas is type I membrane protein, expressed on various tissue including hematopoietic cell. Its ligand (FasL), a member of the tumor necrosis factor (TNF) family, which includes two forms of a membrane-bound form and a soluble one, induces apoptosis of Fas-bearing cells through cytotoxic activity. FasL is undetectable in the serum of healthy person, whereas it is high in that from patients with T-large granular lymphocytic leukemia and natural killer (NK) cell lymphoma. We experienced a case of aggressive NK cell leukemia presenting severe bone marrow necrosis (BMN) after administrating granulocyte colony stimulating factor (G-CSF). In concern with a relation to cytokine, his serum FasL was examined and found to be extremely elevated. Administration of G-CSF under a large quantity of soluble FasL might play an important role in the pathogenesis of BMN through apoptosis of hematopoietic cells in the bone marrow.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords