alexa Bone Marrow Necrosis and Elevated Plasma Levels of Fas Ligand in a Patient with Aggressive Natural Killer Cell Leukemia
ISSN: 2327-5146

General Medicine: Open Access
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Case Report

Bone Marrow Necrosis and Elevated Plasma Levels of Fas Ligand in a Patient with Aggressive Natural Killer Cell Leukemia

Yoshiko (Fujimoto) Hirakawa1*, Kyoko (Taniguchi) Yoshihara2, Hiroto Kaneko3, Hitoji Uchiyama1, Junya Kuroda4 and Masafumi Taniwaki4

1Department of Hematology, Japanese Red Cross Kyoto Daiichi Hospital, Honmachi, Higashiyama-ku, Kyoto, Japan

2Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa-cho, Nishinomiya City, Hyogo, Japan

3Department of Hematology, Aiseikai Yamashina Hospital, Takehana-Shichono-cho, Yamashina-ku, Kyoto, Japan

4Department of Hematology and Oncology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kyoto, Japan

*Corresponding Author:
Yoshiko (Fujimoto) Hirakawa
Department of Hematology
Japanese Red Cross Kyoto Daiichi Hospital
15-749 Honmachi, Higashiyama-ku
Kyoto 605-0981, Japan
Tel: +81-75-561-1121
Fax: +81-75-561-6308
E-mail: [email protected]

Received date: June 28, 2016; Accepted date: July 25, 2016; Published date: July 31, 2016

Citation: Yoshiko (Fujimoto) Hirakawa, Kyoko (Taniguchi) Yoshihara, Hiroto Kaneko, Hitoji Uchiyama, Junya Kurodam, et al. (2016) Bone Marrow Necrosis and Elevated Plasma Levels of Fas Ligand in a Patient with Aggressive Natural Killer Cell Leukemia. Gen Med (Los Angeles) 4:263. doi:10.4172/2327-5146.1000263

Copyright: © 2016 Yoshiko (Fujimoto) Hirakawa, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Fas is type I membrane protein, expressed on various tissue including hematopoietic cell. Its ligand (FasL), a member of the tumor necrosis factor (TNF) family, which includes two forms of a membrane-bound form and a soluble one, induces apoptosis of Fas-bearing cells through cytotoxic activity. FasL is undetectable in the serum of healthy person, whereas it is high in that from patients with T-large granular lymphocytic leukemia and natural killer (NK) cell lymphoma. We experienced a case of aggressive NK cell leukemia presenting severe bone marrow necrosis (BMN) after administrating granulocyte colony stimulating factor (G-CSF). In concern with a relation to cytokine, his serum FasL was examined and found to be extremely elevated. Administration of G-CSF under a large quantity of soluble FasL might play an important role in the pathogenesis of BMN through apoptosis of hematopoietic cells in the bone marrow.


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