Bone Metastasis from Parathyroid Carcinoma Non-avid for 99mTc-MIBI, 99mTc-MDP, and 18F-FDGMaomei Ruan1, Yan Shen2,3, Huizhen Zhang4, Minghua Li3 and Libo Chen1*
- Corresponding Author:
- Libo Chen, MD
Department of Nuclear Medicine
Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
600 Yishan Road, Shanghai 200233, People’s Republic of China
E-mail: [email protected]
Received Date: December 18, 2013; Accepted Date: January 23, 2014; Published Date: January 31, 2014
Citation: Ruan M, Shen Y, Zhang H, Li M, Chen L (2014) Bone Metastasis from Parathyroid Carcinoma Non-avid for 99mTc-MIBI, 99mTc-MDP, and 18F-FDG. J Nucl Med Radiat Ther 5:165. doi:10.4172/2155-9619.1000165
Copyright: © 2014 Ruan M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Nuclear medicine imaging modalities have been reported to be useful in the diagnosis of parathyroid carcinoma (PC). However, false negative findings of bone metastasis from PC have been rarely reported. Here, we describe a patient undergoing nuclear medicine examinations since he had persistent high calcium and parathyroid hormone levels after resection of parathyroid tumor. 99mTc-Sestamibi (99mTc-MIBI) whole body scintigraphy (WBS) and 99mTc-methylene diphosphonate (99mTc-MDP) WBS were both negative. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18FDG-PET/CT) scan demonstrated osteolytic lesion in the fourth lumbar vertebrae (L4) on CT image with no obvious 18F-FDG accumulation on PET image. CT-guided fine needle aspiration and pathalogical examinations confirmed bone metastasis from PC.