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ISSN: 2155-9619

Journal of Nuclear Medicine & Radiation Therapy
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Research Article

Boron Carbide Particle as a Boron Compound for Boron Neutron Capture Therapy

Takaki Iwagami1, Yoshie Ishikawa2, Naoto Koshizaki3, Naofumi Yamamoto4, Hiroki Tanaka5, Shin-ichiro Masunaga5, Yoshinori Sakurai6, Itsuro Kato1, Soichi Iwai1, Minoru Suzuki5, and Yoshiaki Yura1*

1Department of Oral and Maxillofacial Surgery, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Suita, Osaka 565-0871, Japan

2Nanosystem Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba Central 5, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan

3Research Group of Plasma Science and Engineering, Division of Quantum Science and Engineering, Graduate School of Engineering, Kita13, Nishi8, Kita-ku, Sapporo,
Hokkaido 060-8628, Japan

4Department of Oral and Maxillofacial Surgery, Osaka Saiseikai Senri Hospital, 1-1-6 Tsukumodai, Suita, Osaka 565-0862, Japan

5Particle Radiation Oncology Research Center, Research Reactor Institute, Kyoto University, Asashiro-nishi 2, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan

6Department of Radiation Life Science, Research Reactor Institute, Kyoto University, Asashiro-nishi 2, Kumatori-cho, Sennan-gun, Osaka 590-0494, Japan

*Corresponding Author:
Yoshiaki Yura
Department of Oral and Maxillofacial Surgery
Osaka University Graduate School of Dentistry
1-8 Yamadaoka, Suita, Osaka 565-0871, Japan
Tel: +81-6-6987-2941
Fax: +81-6-6879-2170
E-mail: [email protected]

Received date : April 16, 2014; Accepted date : June 20, 2014; Published date : June 30, 2014

Citation: Iwagami T, Ishikawa Y, Koshizaki N, Yamamoto N, Tanaka H, et al. (2014) Boron Carbide Particle as a Boron Compound for Boron Neutron Capture Therapy. J Nucl Med Radiat Ther 5:177. doi: 10.4172/2155-9619.1000177

Copyright: © 2014 Iwagami T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: In boron neutron capture therapy (BNCT), the intravenous administration of boron-containing compounds such as boronophenylalanine (BPA) and borocaptate sodium (BSH) is followed by irradiation with thermal neutrons. In the present study, we determined whether a boron-rich boron carbide (B4C) nanoparticle could be used for BNCT.
Methods: B4C nanoparticles were obtained by the laser fragmentation of boron particles in ethyl acetate. Neutron irradiation was delivered via a neutron beam at the Kyoto University Research Reactor (KUR).
Results: Cell viability was lower in oral squamous cell carcinoma (SCC) cells exposed to neutrons in the presence of B4C particles than in those exposed to neutrons only. The combination of B4C particles and neutron irradiation also decreased the formation of colonies.Injecting B4C particles into the oral SCC xenografts of nude mice increased the concentration of 10B in the tumors, but not in the kidney, liver, or spleen. The body weights of animals were not affected by neutron irradiation to B4C-injected tumors.Tumor volumes were lowerTumor volumes were lower in the B4C- mediated BNCT group than in the neutron group. Conclusion: These results indicate that B4C particles can be used locally as a boron compound in BNCT for oral SCC.


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