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Brain Angiotensin-II-derived Reactive Oxygen Species: Implications for High Blood Pressure | OMICS International | Abstract
ISSN: 2167-1095

Journal of Hypertension: Open Access
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Review Article

Brain Angiotensin-II-derived Reactive Oxygen Species: Implications for High Blood Pressure

Alynne S. Carvalho, Drielle D. Guimaraes, Bruna P. V. Dantas, Juliana N. Carreiro, Leonidas G. Mendes-Junior, Maria S. França-Silva, Matheus M.O. Monteiro, Naiane F.B. Alves, Suênia K.P. Porpino,Thyago M. Queiroz and Valdir A. Braga*

Biotechnology Center, Federal University of Paraiba, João Pessoa, PB, Brazil

*Corresponding Author:
Valdir Andrade Braga, PhD
Biotechnology Center, Federal University of Paraiba
Caixa Postal 5009, 58.051-970
João Pessoa, PB, Brazil
Tel: (55) 83 3216 7511
E-mail: [email protected]

Received Date: May 22, 2012; Accepted Date: July 24, 2012; Published Date: July 26, 2012

Citation: Carvalho AS, Guimaraes DD, Dantas BPV, Carreiro JN, Mendes- Junior LG, et al. (2012) Brain Angiotensin-II-derived Reactive Oxygen Species: Implications for High Blood Pressure. J Hypertens 1:107. doi: 10.4172/2167-1095.1000107

Copyright: © 2012 Carvalho AS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Hypertension and its relation to free radicals have been matter of continuous research worldwide. This review is based on the premise that some forms of neurogenic hypertension is, in part, caused by the formation of Angiotensin- II (Ang II)-derived reactive oxygen species within the brain, especially in areas along the Subfornical Organ- Paraventricular Nucleus of the Hypothalamus-Rostral Ventrolateral Medulla pathway (SFO-PVN-RVLM pathway). Here we will discuss the recent contribution of our laboratory and others regarding the mechanisms by which neurons in the Rostral Ventrolateral Medulla (RVLM) are activated by Ang II, how they communicate with the SFO and PVN and more importantly, how Ang II-derived Reactive Oxygen Species (ROS) participate along the SFO-PVN-RVLM pathway in the pathogenesis of neurogenic hypertension.