alexa Brain Protection Effect of Lidocaine Measured By Interleukin-6 and Phospholipase A2 Concentration in Epidural Haematoma with Moderate Head Injury Patient
ISSN: 2155-6148

Journal of Anesthesia & Clinical Research
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Brain Protection Effect of Lidocaine Measured By Interleukin-6 and Phospholipase A2 Concentration in Epidural Haematoma with Moderate Head Injury Patient

Diana Ch Lalenoh1*, Tatang Bisri2 and Irawan Yusuf3

1 Bagian Anestesiologi dan Terapi Intensif, Fakultas Kedokteran, Universitas Sam Ratulangi Manado, Indonesia

2 Bagian Anestesiologi dan Terapi Intensif, Fakultas Kedokteran, Universitas Padjajaran Bandung, Indonesia

3 Bagian Fisiologi dan Biomolekuler, Fakultas Kedokteran, Universitas Hasanuddin Makassar, Indonesia

*Corresponding Author:
Diana Ch Lalenoh
Anesthesiology Department– Medical Faculty of Sam Ratulangi University-Manado
Indonesia
Tel: +6281340601366, +6281340242469
E-mail: [email protected]

Received date: January 27, 2014; Accepted date: March 01, 2014; Published date: March 03, 2014

Citation: Lalenoh DC, Bisri T, Yusuf I (2014) Brain Protection Effect of Lidocaine Measured By Interleukin-6 and Phospholipase A2 Concentration in Epidural Haematoma with Moderate Head Injury Patient. J Anesth Clin Res 5:388. doi: 10.4172/2155-6148.1000388

Copyright: © 2014 Lalenoh DC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The aim of this study is to find out the neuroprotective mechanism of lidocaine in epidural haematoma (EDH) in moderate brain injury. The effects are measured by the level of interleukin-6 (IL-6) and phospholipase A2 (PLA2). This study is done in forty epidural haematoma patients with moderate brain injury. The objects are divided into two groups, group A with NaCl 0.9% infusion only (control) and group B with NaCl 0.9% infusion combined with lidocaine 1 mg/kg/hr. The blood samples were taken right before induction and two hours after infusion.

The result shows that the level of IL-6 and PLA2 is significantly low in group B (p<0.005) with Mann Whitney and Dependent t test. The decreasing level of IL-6 and PLA2 is related with the dose of lidocaine. The inhibition mechanism of IL-6 and PLA2 secretion by lidocaine is considered as a responsible factor in inflammation and brain cells damage.

Summary

• Infusion of lidocaine 1 mg/kg/hr will decrease the level of IL-6 in moderate brain injury

• Infusion of lidocaine 1 mg/kg/hr will decrease the level of PLA2 in moderate brain injury

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version