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ISSN: 1948-5956

Journal of Cancer Science & Therapy
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Research Article

Breast Cancer and Pregnancy: Experience of Maternity and Neonatology Center of Tunis-Tunisia

Achour Radhouane1*, Magdoud Khawla1, Hmila Tarek1, Ben Jemaa Nadia2, Chanoufi Mohamed Badis3, Khila Mehdi3, Chelly Dalenda4, Malek Monia5, Rzega Hedi5 and Neji Khaled1

1Emergency Department of Maternity and Neonatology Center, Faculty of Medicine of Tunis, El-Manar University of Tunis, Tunisia

2Fetopathology Department of Maternity and Neonatology Center, Faculty of Medicine of Tunis, El-Manar University of Tunis, Tunisia

3Department “C” of Maternity and Neonatology Center, Faculty of Medicine of Tunis, El-Manar University of Tunis, Tunisia

4Department “A” of Maternity and Neonatology Center, Faculty of Medicine of Tunis, El-Manar University of Tunis, Tunisia

5Department “B” of Maternity and Neonatology Center, Faculty of Medicine of Tunis, El-Manar University of Tunis, Tunisia

*Corresponding Author:
Achour Radhouane
Emergency Department of Maternity and Neonatology Center
Faculty of Medicine of Tunis, El-Manar University of Tunis, Tunisia
Tel: 21698549398
E-mail: [email protected]

Received Date: May 05, 2017; Accepted Date: May 10, 2017; Published Date: May 15, 2017

Citation: Radhouane A, Khawla M, Tarek H, Nadia BJ, Badis CM, et al. (2017) Breast Cancer and Pregnancy: Experience of Maternity and Neonatology Center of Tunis-Tunisia. J Cancer Sci Ther 9:445-450. doi: 10.4172/1948-5956.1000457

Copyright: © 2017 Radhouane A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Objectives: This document aims to identify the clinical, therapeutic, and prognostic features of this association and to provide the up-to-date management.

Methods and materials: Our study design is retrospective based on 25 cases of pregnancy-associated breast cancer, carried out at the Maternity and Neonatology Center of Tunis over a period of 10 years, between January 2001 and December 2013.

Results: The mean age of the patients was 35.84 years. Breast cancer was diagnosed during pregnancy in fourteen patients and after delivery in eleven patients. Pathohistological diagnosis was established by ultrasoundguided biopsy and surgical biopsy in fourteen and seven patients, respectively. The most common histological type was infiltrating ductal carcinoma (96% of cases). Pregnancy was completed in nine patients. The mean gestational age at which delivery occurred was 35.4 weeks. Twenty patients underwent surgical treatment by mastectomy and breast-conserving surgery (lumpectomy) associated with axillary lymph node dissection was performed in three cases. Chemotherapy was allowed during pregnancy, and was given to 23 patients. On the other hand, radiotherapy, antiestrogens (Tamoxifene) and targeted therapies (Herceptin) must be postponed after delivery because of their teratogenic effects. After a 5-year follow-up, two of eighteen patients died and six were lost to follow-up.

Conclusion: The poor prognosis of the pregnancy-associated breast cancer is no longer attributed to pregnancy but rather to the young age of the patients and the delay in the diagnosis of cancer. Treatment should be started promptly during pregnancy.

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