Breath Alcohol Concentration in Japanese Breast Cancer Patients Following Alcohol-Containing Chemotherapeutic Agent Infusion
|Naoko Itoi1,2, Hajime Abe2,3*, Tsuyoshi Mori2, Yuki Kawai2, Yoshihiro Kubota2, Tomoko Umeda2and Tohru Tani4|
|1Department of Surgery, Hino Memorial Hospital, Japan|
|2Division of Breast and General Surgery, Shiga University of Medical Science Hospital, Japan|
|3Breast Center, Bell Land General Hospital, Japan|
|4Department of Surgery, Shiga University of Medical Science, Japan|
|Corresponding Author :||Hajime Abe, M.D., Ph.D.
Breast Center, Bell Land General Hospital
500-3 Higashiyama, Naka-ku, Sakai
Osaka 599-8247, Japan
E-mail: [email protected]
|Received July 07, 2014; AcceptedJuly 22, 2014; Published July 29, 2014|
|Citation: Itoi N, Abe H, Mori T, Kawai Y, Kubota Y, et al. (2014) Breath Alcohol Concentration in Japanese Breast Cancer Patients Following Alcohol-Containing Chemotherapeutic Agent Infusion. J Pharmacovigilance 2:138. doi: 10.4172/2329-6887.1000138|
|Copyright: © 2014 Itoi N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use,distribution, and reproduction in any medium, provided the original author and source are credited|
|Related article at
Pubmed Scholar Google
Background: Preparations containing dehydrated ethanol as an additive, due to its water-insoluble properties, have been frequently used for chemotherapeutic agents, such as paclitaxel (PTX), docetaxel (DOC) and eribulin. When selecting these drugs, the influence of alcohol on the central nervous system (CNS) must be considered. In this study, we measured the breath alcohol concentration (BAC) in Japanese breast cancer patients treated with these agents.
Method: Japanese patients with breast cancer receiving outpatient chemotherapy with alcohol-containing agents were registered. The BAC was measured immediately after drip infusion and 30 and 60 minutes later.
Result: Thirty-one female patients were enrolled in this study. Breath alcohol was detected in 18 patients (58%) immediately after administration: 6 patients (75%) with PTX, 10 (50%) with DOC and 2 (67%) with eribulin. After 30 minutes, no patient had BAC over 0.15 mg/L, but breath alcohol under 0.1 mg/L was detected in 1 patient with PTX and 1 with DOC after 60 minutes.
Conclusion: The influence of alcohol may disappear 60 minutes or more after administration, making it possible to travel home safely at this time.