alexa Breathing Intolerance Index and Control of Ventilation, a Non-invasive Method for Evaluating Inspiratory Muscle Endurance at Rest and Exercise, in Patients with Cardiomyopathy: One Year Follow-up| Abstract
ISSN: 2161-105X

Journal of Pulmonary & Respiratory Medicine
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.
  • Research Article   
  • J Pulm Respir Med 2017, Vol 7(6): 440
  • DOI: 10.4172/2161-105X.1000440

Breathing Intolerance Index and Control of Ventilation, a Non-invasive Method for Evaluating Inspiratory Muscle Endurance at Rest and Exercise, in Patients with Cardiomyopathy: One Year Follow-up

Kavitha Bagavathy1, Michael Fong2, Luanda Grazette2, Zhanghua Chen3 and Ahmet Baydur1*
1Division of Pulmonary, Critical Care and Sleep Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA
2Division of Cardiovascular Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA
3Department of Preventive Medicine, Division of Biostatistics, Keck School of Medicine, University of Southern California, Los Angeles, USA
*Corresponding Author : Ahmet Baydur, Division of Pulmonary, Critical Care and Sleep Medicine, Keck School of Medicine, University of Southern California, Los Angeles, USA, Tel: 3234097184, Fax: 3232267238, Email: [email protected]

Received Date: Dec 21, 2017 / Accepted Date: Dec 26, 2017 / Published Date: Dec 29, 2017

Abstract

Rationale: Inspiratory muscle endurance as expressed by the tension-time index of the diaphragm [TTI=(Pdi/ Pdimax) × (Ti/Ttot)] in normal subjects and cardiorespiratory disorders requires the use of esophageal and gastric balloons. A noninvasive technique can be used in which the ratio of tidal volume to vital capacity (Vt/VC) is substituted for Pdi/Pdimax, with the resulting relationship [(Ti/Ttot) × (Vt/FVC)] called the breathing intolerance index (BIT). The response to medical management of BIT in patients with cardiomyopathy with chronic heartfailure has not been assessed before and after medical management.
Objectives: To compare control of ventilation and BIT in patients with stable dilated cardiomyopathy at rest and exercise, and to analyze BIT, oxygen uptake and carbon dioxide elimination at baseline and approximately one year after initiating medical management.
Methods: Control of ventilation and BIT were assessed in 24 patients (mean age 55.5 years; 17 males) at rest and at peak exercise during bicycle ergometry, at baseline and approximately 14 months later.
Results: Median peak VO2 was 12.9 mL/kg/min and 14.3 mL/kg/min at baseline and followup, respectively (p<0.036, adjusted for age, gender and BMI). It increased 4.3 times from rest to peak exercise at baseline and 4.7 times at followup (NS). Peak V’O2 increased by 10.5% between baseline and followup (p=0.036 after adjusting for age, sex and BMI). BIT did not change significantly. Peak V’O2/BIT increased significantly from baseline to follow-up (p=0.008, adjusted for age, sex and BMI). No patients died or experienced acute heart failure during the study.
Conclusions: Peak V’O2 in relation to non-invasively measured peak tension-time index of the respiratory muscles (BIT) increases significantly after one year of medical management, indicating increased efficient oxygen utilization as cardiac function improves. BIT is useful for noninvasively assessing inspiratory muscle endurance and relating oxygen uptake to ventilation in patients with dilated cardiomyopathy and chronic congestive heart failure

Keywords: Breathing intolerance index; Exercise; Cardiomyopathy; Control of ventilation

Citation: Bagavathy K, Fong M, Grazette L, Chen Z, Baydur A (2017) Breathing Intolerance Index and Control of Ventilation, a Non-invasive Method for Evaluating Inspiratory Muscle Endurance at Rest and Exercise, in Patients with Cardiomyopathy: One Year Follow-up. J Pulm Respir Med 7: 440. Doi: 10.4172/2161-105X.1000440

Copyright: © 2017 Bagavathy K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Select your language of interest to view the total content in your interested language

Post Your Comment Citation
Share This Article
Recommended Conferences
Viewmore
Article Usage
  • Total views: 1694
  • [From(publication date): 0-2017 - Jul 21, 2019]
  • Breakdown by view type
  • HTML page views: 1637
  • PDF downloads: 57
Leave Your Message 24x7
Top