Brief Overview of Various Approaches to Enhance Drug Solubility
- *Corresponding Author:
- Syed AA Rizvi
Department of Pharmaceutical Sciences, College of Pharmacy
Nova Southeastern University, 3200 South University Drive
Fort Lauderdale, FL 33328, USA
E-mail: [email protected]
Received Date: November 25, 2013; Accepted Date: December 27, 2013; Published Date: December 30, 2013
Citation: Hart ML, Do DP, Ansari RA, Rizvi SAA (2013) Brief Overview of Various Approaches to Enhance Drug Solubility. J Develop Drugs 2: 115. doi: 10.4172/2329-6631.1000115
Copyright: © 2013 Hart ML, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Aqueous solubility is one of the most influencing factors when it comes to bioavailability of the drugs. It is the main key for drug effectiveness and enhancing water solubility, which poses one of the greatest challenges in the pharmaceutical industry. Nearly half of newly developed drugs turn out to be insoluble or poorly soluble during initial screening process. Poor solubility limits drug delivery and formulation development. Various techniques have been developed to enhance solubility of poorly soluble drugs. Pharmaceuticals falling under the Biopharmaceutics Classification System (BCS) class II and IV are the main emphasis of this review as these drugs are of low solubility. The methods to improve drug solubility; solid dispersions, cyclodextrin complexation, dendrimers, nano-suspensions, co-solvency, pH adjustment, self-emulsifying drug delivery system, hydrotrophy, cocrystallization and ionic liquid formation are discussed.